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Dr Christo Christov

Dr Christo Christov is Senior Lecturer in Computational Biochemistry in the Department of Biomedical Sciences.  He graduated in Biochemistry from the University of Sofia ‘St Kliment Ohridski’, Sofia, Bulgaria and received a PhD in Computational Biochemistry from Bulgarian Academy of Sciences, Sofia, Bulgaria.

Dr Christov's research interests are in the field of computational and theoretical biochemistry and biomolecular modelling. He investigates the structure, spectra and dynamics of proteins and reaction mechanisms of enzymes using an ensemble of quantum chemistry, combined quantum mechanics and molecular mechanics (QM/MM) and molecular dynamics methods. He also investigates the electronic structure and mechanisms of metal-containing enzymes (non-heme iron enzymes) utilising spectroscopy-directed electronic structure methods in collaboration with Prof Edward I Solomon in Department of Chemistry, Stanford University, USA.  

Research Funding

Marie Curie Outgoing International Fellowship for Career Development Grant for Stanford University (2 years) and Northumbria University (1 year); Total amount 336 000 €

Fulbright Senior Research Grant for an integrated computational and spectroscopic investigation of metaloenzymes with Stanford University (Prof E Solomon) 2010-2011 $20000

High Performance Computing - Europe Research Grant for visiting Department of Biochemistry (Prof Mark Sansom), University of Oxford (June-November 2009) directed on "Multilevel Modelling of GPCRs".

Principal Investigator of Grant “Molecular modelling of enzyme reaction mechanisms”, supported from NATO, 2004-2005 € 25000

Principal investigator of Grant MU-X-1001/2001: “Modelling of Tryptophil-Protein Intercations”, supported by Bulgarian Science Foundation 2001-2003. € 6000

Principal investigator of Grant MU-X-1202/2002: “QM/MM Modeling of the enzyme mechanisms of lactamases”, supported by Bulgarian Science Foundation, 2003-2005 € 10000

High Performance Computing - Europe Research Grant “QM/MM modelling of kinase mechanisms” in Group of Molecular Recognition and Bioinformatics, Barcelona Scientific Park, University of Barcelona, Spain (3 months), Spain

Research Grant “QM/MM modelling of methlytransferase mechanisms” CTESIN/2004019 from Valencia Autonomy Government, Spain, 2004 € 10000

DAAD research fellowship in Laboratory of Theoretical Chemistry (Prof Joerg Fleischhauer), Institute of Organic Chemistry, Technical University - Aachen, Germany “Theoretical study of mechanisms of generation of rotational strengths in proteins, 2000  €10000

Selected Publications

T. Karabencheva, C Christov and J Giraldo (2010) Long-range conformational dynamics of G protein-coupled receptor kinase 2, In: Science and Supercomputing in Europe, in press

C Christov and M. Orozco (2006) Computational Insight in Protein Kinases Catalysis from Combined Quantum Mechanical and Molecular Mechanical (QM/MM) Simulations. In: Science and Supercomputing in Europe, Eds P. Alberigo, G Erbacci and F. Garofalo, 63-66

C. Christov and B. Atanasov (2000) Conformation Model of TEM-1 lactamase. In: Currents in Computational Molecular Biology, Eds. S. Miyano, R. Shamir and T.Takagi. Universal Academic Press Inc, Tokyo, Japan, 154-156

Journals

Christo Christov, Patricia González-Bulnes, Fanny Malhaire, Tatyana Karabencheva, Cyril Goudet, Jean-Philippe Pin, Amadeu Llebaria and Jesús Giraldo (2011), Integrated Synthetic, Pharmacological and Computational Investigation ofcis 2 (3,5 dichlorophenylcarbamoyl) cyclohexane carboxylic acid enantiomers as Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 4, ChemMedChem, 6, 1, 131-140 DOI: 10.1002/cmdc. 201000378

T Karabencheva and C. Christov , (2010), Mechanisms of Protein Circular Dichroism: Insights from Computational Modelling, Invited review article Advances in Protein Chemistry and Structural Biology, 80, 85-115

T. Karabencheva, R. Donev, Kia Balali-Mood and C. Christov (2010) Individual Contributions of the Aromatic Chromophores to the Near-UV Circular Dichroism in Class A β-lactamases: A Comparative Computational Analysis, Biophysical Chemistry, 151 (1-2): 39-45, DOI: 10.1016/ j.bpc.2010.05.003 

For a full list of publications, please click here.