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Dr Kathryn Garner

Senior Lecturer

Department: Applied Sciences

I studied for my PhD in the Lipid Signalling Group at UCL with Professor Shamshad Cockcroft, before moving to the University of Bristol for my post-doctoral work. In Bristol, I investigated Gonadotropin-releasing hormone (GnRH) sensing with Professor Craig McArdle, and later worked with Professor Richard Coward in Bristol Renal on diabetic nephropathy. I currently hold a Kidney Research UK Intermediate Fellowship to investigate the relationship between high blood pressure (Angiotensin II) and inflammation (TNF) sensing by kidney podocytes. I am a previous recipient of a Society for Endocrinology Early Career Grant, and a BrisSynBio Big Ideas in BioDesign Award (Bristol BioDesign Institute, BBSRC). I have been a member of the Biochemical Society Education, Training and Public Engagement committee since 2016. 

I joined the Department of Applied Sciences in April 2020 as Senior Lecturer in Cellular and Molecular Sciences. I am Module Tutor for the level 4 Biochemistry module (AP0407).

Kathryn Garner

Research Themes and Scholarly Interests

My research examines how mammalian cells sense and respond to signals in their environment, and how inherent cell-cell variability affects this behaviour. I currently hold a Kidney Research UK Intermediate Fellowship to investigate the relationship between high blood pressure (Angiotensin II) and inflammation (TNF) signalling in kidney podocytes, the cells which form the specialised sieve in the glomerulus, which filters waste products from the blood into the urine. Damage or loss of these cells can lead to essential proteins being lost from the blood (proteinuria), causing kidney damage and ultimately, chronic kidney disease.

My work is interdisciplinary; I use high content imaging (automated fluorescence microscopy) for quantitative analysis of signalling pathway dynamics, and I have worked with mathematicians, statisticians, and computer scientists to develop mathematical models, and with electronic engineers to build an LED device for optogenetic control of signalling pathways.

I have an undergraduate degree in fine art, and I am currently exploring ways in which art can be used to teach biochemistry, particularly drawing and spatial learning techniques. I am interested in how art can be used to open up conversations about scientific research with the public. As a member of the Biochemical Society Education, Training and Public Engagement committee, I am involved in developing an art and science programme of public engagement.

Key Publications

  • Please visit the Pure Research Information Portal for further information
  • An information theoretic approach to insulin sensing by human kidney podocytes, Pope, R., Garner, K., Voliotis, M., Lay, A., Betin, V., Tsaneva-Atanasova, K., Welsh, G., Coward, R., McArdle, C. 1 Dec 2020, In: Molecular and Cellular Endocrinology
  • High content imaging for monitoring signalling dynamics in single cells, Garner, K. 1 Nov 2020, In: Journal of Molecular Endocrinology
  • Authors response to communication about mathematical modeling of gonadotropin-releasing hormone signaling, Pratap, A., Garner, K., Voliotis, M., Tsaneva-Atanasova, K., McArdle, C. 15 Jul 2018, In: Molecular and Cellular Endocrinology
  • Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress, Garner, K., Betin, V., Pinto, V., Graham, M., Abgueguen, E., Barnes, M., Bedford, D., McArdle, C., Coward, R. Dec 2018, In: Scientific Reports
  • Exploring Dynamics and Noise in Gonadotropin-Releasing Hormone (GnRH) Signaling, Voliotis, M., Garner, K., Alobaid, H., Tsaneva-Atanasova, K., McArdle, C. 2018, Computational Cell Biology, Springer
  • Gonadotropin-releasing hormone signaling: An information theoretic approach, Voliotis, M., Garner, K., Alobaid, H., Tsaneva-Atanasova, K., McArdle, C. 5 Mar 2018, In: Molecular and Cellular Endocrinology
  • Information Transfer via Gonadotropin-Releasing Hormone Receptors to ERK and NFAT: Sensing GnRH and Sensing Dynamics, Garner, K., Voliotis, M., Alobaid, H., Perrett, R., Pham, T., Tsaneva-Atanasova, K., McArdle, C. 1 Apr 2017, In: Journal of the Endocrine Society
  • Mathematical modeling of gonadotropin-releasing hormone signaling, Pratap, A., Garner, K., Voliotis, M., Tsaneva-Atanasova, K., McArdle, C. 5 Jul 2017, In: Molecular and Cellular Endocrinology
  • Information Transfer in Gonadotropin-releasing Hormone (GnRH) Signaling: EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK)-MEDIATED FEEDBACK LOOPS CONTROL HORMONE SENSING, Garner, K., Perrett, R., Voliotis, M., Bowsher, C., Pope, G., Pham, T., Caunt, C., Tsaneva-Atanasova, K., McArdle, C. 29 Jan 2016, In: The Journal of Biological Chemistry
  • RdgBα reciprocally transfers PA and PI at ER–PM contact sites to maintain PI(4,5)P2 homoeostasis during phospholipase C signalling in Drosophila photoreceptors, Cockcroft, S., Garner, K., Yadav, S., Gomez-Espinosa, E., Raghu, P. 15 Feb 2016, In: Biochemical Society Transactions

Professional Activity

Qualifications

  • Physiology PhD September 28 2012
  • Molecular Biology BSc (Hons)
  • Fine Art BA (Hons)


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