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Dr Edwin Lasonder

Senior Lecturer

Department: Applied Sciences

Edwin Lasonder

Research Themes and Scholarly Interests

My research interests are developing mass spectrometry-based proteomics applications for studying human diseases such as malaria and cancers. Malaria remains one of the most lethal infectious diseases around the world and is caused by the Apicomplexan parasite Plasmodium falciparum. The life cycle of the parasite is complex and composed of several developmental stages in mosquito and human hosts. Throughout out my professional career I have used state-of-the art proteomic technologies to identify targets for intervention strategies at different stages of the parasite life cycle since the P falciparum genome was sequenced and was the first in publishing global proteomes of the human malaria parasite at various life cycle stages.  Since then I have been studying the biology of the parasite P. falciparum in human host for the development of novel intervention strategies using a variety of methods including expression profiling, post-translational modification (PTM) studies and protein-protein interaction network analyses. 

Qualifications

  • Microbiology PhD November 15 1995
  • Fellow (FHEA) Higher Education Academy (HEA) 2020

Key Publications

  • Please visit the Pure Research Information Portal for further information
  • NAD(P) transhydrogenase has vital non-mitochondrial functions in malaria parasite transmission, Saeed, S., Tremp, A., Sharma, V., Lasonder, E., Dessens, J. 4 Mar 2020, In: EMBO Reports
  • Plasmodium berghei LAPs form an extended protein complex that facilitates crystalloid targeting and biogenesis, Tremp, A., Saeed, S., Sharma, V., Lasonder, E., Dessens, J. 15 Sep 2020, In: Journal of Proteomics
  • Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development, Green, J., Wu, Y., Encheva, V., Lasonder, E., Prommaban, A., Kunzelmann, S., Christodoulou, E., Grainger, M., Truongvan, N., Bothe, S., Sharma, V., Song, W., Pinzuti, I., Uthaipibull, C., Srichairatanakool, S., Birault, V., Langsley, G., Schindelin, H., Stieglitz, B., Snijders, A., Holder, A. 22 Jun 2020, In: PLoS Pathogens
  • Vesiculation of Red Blood Cells in the Blood Bank: A Multi-Omics Approach towards Identification of Causes and Consequences, Freitas Leal, J., Lasonder, E., Sharma, V., Schiller, J., Fanelli, G., Rinalducci, S., Brock, R., Bosman, G. 31 Mar 2020, In: Proteomes
  • Proteomic analysis discovers the differential expression of novel proteins and phosphoproteins in meningioma including NEK9, HK2 and SET and deregulation of RNA metabolism, Dunn, J., Ferluga, S., Sharma, V., Futschik, M., Hilton, D., Adams, C., Lasonder, E., Hanemann, C. 1 Feb 2019, In: EBioMedicine
  • Publisher Correction: Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity (Nature communications (2018) 9 1 (558)), Stone, W., Campo, J., Ouédraogo, A., Meerstein-Kessel, L., Morlais, I., Da, D., Cohuet, A., Nsango, S., Sutherland, C., van de Vegte-Bolmer, M., Siebelink-Stoter, R., van Gemert, G., Graumans, W., Lanke, K., Shandling, A., Pablo, J., Teng, A., Jones, S., de Jong, R., Fabra-García, A., Bradley, J., Roeffen, W., Lasonder, E., Gremo, G., Schwarzer, E., Janse, C., Singh, S., Theisen, M., Felgner, P., Marti, M., Drakeley, C., Sauerwein, R., Bousema, T., Jore, M. Dec 2018, In: Nature Communications
  • Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity, Stone, W., Campo, J., Ouédraogo, A., Meerstein-Kessel, L., Morlais, I., Da, D., Cohuet, A., Nsango, S., Sutherland, C., Van De Vegte-Bolmer, M., Siebelink-Stoter, R., Van Gemert, G., Graumans, W., Lanke, K., Shandling, A., Pablo, J., Teng, A., Jones, S., De Jong, R., Fabra-García, A., Bradley, J., Roeffen, W., Lasonder, E., Gremo, G., Schwarzer, E., Janse, C., Singh, S., Theisen, M., Felgner, P., Marti, M., Drakeley, C., Sauerwein, R., Bousema, T., Jore, M. 1 Dec 2018, In: Nature Communications
  • Clinical proteomics: From biological sample to clinical exploitation, Lasonder, E. 1 Jun 2017, In: Proteomes
  • Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target, Bassiri, K., Ferluga, S., Sharma, V., Syed, N., Adams, C., Lasonder, E., Hanemann, C. 1 Feb 2017, In: EBioMedicine
  • LCCL protein complex formation in Plasmodium is critically dependent on LAP1, Tremp, A., Sharma, V., Carter, V., Lasonder, E., Dessens, J. 1 Jun 2017, In: Molecular and Biochemical Parasitology


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