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Dr Kay Padget

Senior Lecturer

Department: Applied Sciences

Upon completion of a BSc (Hons) in Biomedical Science at Sunderland University, Dr Padget gained her PhD in Biochemistry at Newcastle University in 1998 in which she developed quantitative methodologies to determine levels of DNA Topoisomerase II (Topo II) in Acute Lymphoblastic Leukaemia patients to understand their therapeutic responses and evaluate the potential of personalised therapy. Dr Padget continued her research on the biochemistry of Topo II and its role as a therapeutic target and in DNA repair at Newcastle University until 2007 when she joined Northumbria University.

Dr Padget current research reflects her interest in ageing mechanisms, centred around Topo II and also childhood Leukaemia.  In addition, she teaches on a range of Biomedical Science undergraduate modules as well as the first year of the four-year Doctor of Medicine (MD) programme ran in partnership with St. George’s University of Grenada School of Medicine (SGU). She is a Senior Fellow of the Higher Education Academy (SFHEA) in recognition of her teaching practice and support for students and staff and mentors’ new staff in gaining professional recognition as well as assessing applications. Dr Padget is also an External Examiner at Salford University and is a member of the Applied Sciences Athena Swan Committee.

Dr Padget is currently Deputy Head of the Applied Sciences Department at Northumbria and provides support to ensure the effective and efficient running of the Department in line with University Strategy and Vision.

Kay Padget

Research Themes and Scholarly Interests

My research focus is on neuronal aging, with an emphasis on understanding the molecular mechanisms underpinning observed decreases in DNA Topoisomerase II beta (TOP2B) with aging. This includes investigating the epigenetic mechanisms underpinning decreased expression and the impact on DNA repair and transcription as a result. In collaboration, I am also involved in investigating the mechanisms of the developmental origins of translocations seen in childhood leukaemia and therapy-related translocations. 

Key Publications

  • Please visit the Pure Research Information Portal for further information
  • Exercise Training-Induced Extracellular Matrix Protein Adaptation in Locomotor Muscles: A Systematic Review, Kritikaki, E., Asterling, R., Ward, L., Padget, K., Barreiro, E., Camargo Madeira Simoes, D. 26 Apr 2021, In: Cells
  • Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes, Lee, K., Swan, R., Sondka, Z., Padget, K., Cowell, I., Austin, C. 14 Jul 2018, In: International Journal of Molecular Sciences
  • Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells, Manville, C., Smith, K., Sondka, Z., Rance, H., Cockell, S., Cowell, I., Lee, K., Morris, N., Padget, K., Jackson, G., Austin, C. Nov 2015, In: Biology Open
  • Leptin up-regulates TLR2 in human monocytes, Jaedicke, K., Roythorne, A., Padget, K., Todryk, S., Preshaw, P., Taylor, J. 22 Apr 2013, In: Journal of Leukocyte Biology
  • Model for MLL translocations in therapy-related leukemia involving topoisomerase II -mediated DNA strand breaks and gene proximity, Cowell, I., Sondka, Z., Smith, K., Lee, K., Manville, C., Sidorczuk-Lesthuruge, M., Rance, H., Padget, K., Jackson, G., Adachi, N., Austin, C. 2012, In: Proceedings of the National Academy of Sciences of the United States of America
  • MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA, Lee, K., Padget, K., Curtis, H., Cowell, I., Moiani, D., Sondka, Z., Morris, N., Jackson, G., Cockell, S., Tainer, J., Austin, C. 2012, In: Biology Open
  • Histone deacetylase inhibition redistributes topoisomerase IIb from heterochromatin to euchromatin, Cowell, I., Papageorgiou, N., Padget, K., Watters, G., Austin, C. 2011, In: Nucleus
  • Curcumin Induces High Levels of Topoisomerase I− and II−DNA Complexes in K562 Leukemia Cells, López-lázaro, M., Willmore, E., Jobson, A., Gilroy, K., Curtis, H., Padget, K., Austin, C. Dec 2007, In: Journal of Natural Products
  • mAMSA resistant human topoisomerase II  mutation G465D has reduced ATP hydrolysis activity, Gilroy, K., Leontiou, C., Padget, K., Lakey, J., Austin, C. 1 Jan 2006, In: Nucleic Acids Research
  • Deacetylase Activity Associates with Topoisomerase II and Is Necessary for Etoposide-induced Apoptosis, Johnson, C., Padget, K., Austin, C., Turner, B. 16 Feb 2001, In: Journal of Biological Chemistry

PGR Supervision

  • Ashleigh Roythorne Exploring the Role of Topoisomerase II Beta in Macrophage Maturation and Pro-Inflammatory Cytokine Production Start Date: 10/01/2011 End Date: 13/11/2014
  • Callum Bainbridge Investigating the Expression of Topoisomerase II Beta in Aged Neurons: Development of a Murine Cell Line and Drosophila Model’ Start Date: 01/10/2016 End Date: 03/03/2021

Qualifications

  • Teaching & Learning PCAPL October 11 2007
  • Biochemistry PhD September 01 1994
  • Fellow of The Higher Education Academy FHEA 2011
  • Senior Fellow of The Higher Education Academy SFHEA 2018


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