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Dr Kay Padget

Senior Lecturer

Department: Applied Sciences



Upon completion of a BSc in Biomedical Science at Sunderland University, Dr Padget gained her PhD in Biochemistry at Newcastle University in 1998 and continued to pursue her research there until 2007 when she joined Northumbria University.


  • Teaching & Learning PCAPL October 11 2007
  • Biochemistry PhD September 01 1994
  • Fellow (FHEA) Higher Education Academy (HEA) 2011

Key Publications

  • Please visit the Pure Research Information Portal for further information
  • Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes, Lee, K., Swan, R., Sondka, Z., Padget, K., Cowell, I., Austin, C. 14 Jul 2018, In: International Journal of Molecular Sciences
  • Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells, Manville, C., Smith, K., Sondka, Z., Rance, H., Cockell, S., Cowell, I., Lee, K., Morris, N., Padget, K., Jackson, G., Austin, C. Nov 2015, In: Biology Open
  • Leptin up-regulates TLR2 in human monocytes, Jaedicke, K., Roythorne, A., Padget, K., Todryk, S., Preshaw, P., Taylor, J. 22 Apr 2013, In: Journal of Leukocyte Biology
  • Model for MLL translocations in therapy-related leukemia involving topoisomerase II -mediated DNA strand breaks and gene proximity, Cowell, I., Sondka, Z., Smith, K., Lee, K., Manville, C., Sidorczuk-Lesthuruge, M., Rance, H., Padget, K., Jackson, G., Adachi, N., Austin, C. 2012, In: Proceedings of the National Academy of Sciences of the United States of America
  • MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA, Lee, K., Padget, K., Curtis, H., Cowell, I., Moiani, D., Sondka, Z., Morris, N., Jackson, G., Cockell, S., Tainer, J., Austin, C. 2012, In: Biology Open
  • Histone deacetylase inhibition redistributes topoisomerase IIb from heterochromatin to euchromatin, Cowell, I., Papageorgiou, N., Padget, K., Watters, G., Austin, C. 2011, In: Nucleus
  • Curcumin Induces High Levels of Topoisomerase I− and II−DNA Complexes in K562 Leukemia Cells, López-lázaro, M., Willmore, E., Jobson, A., Gilroy, K., Curtis, H., Padget, K., Austin, C. Dec 2007, In: Journal of Natural Products
  • mAMSA resistant human topoisomerase II  mutation G465D has reduced ATP hydrolysis activity, Gilroy, K., Leontiou, C., Padget, K., Lakey, J., Austin, C. 1 Jan 2006, In: Nucleic Acids Research
  • Deacetylase Activity Associates with Topoisomerase II and Is Necessary for Etoposide-induced Apoptosis, Johnson, C., Padget, K., Austin, C., Turner, B. 16 Feb 2001, In: Journal of Biological Chemistry
  • An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2,1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells, Padget, K., Stewart, A., Charlton, P., Tilby, M., Austin, C. 15 Sep 2000, In: Biochemical Pharmacology

PGR Supervision

Callum Bainbridge Determination of the Expression of Topoisomerase II Beta in Aged Neurons and It's Role in Maintaining Genomic Integrity Start: 01/10/2016

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