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Michail (Mihalis) Panagiotidis

Professor of Cellular & Molecular Sciences

Department: Applied Sciences

Mihalis is leading a research group which conducts research on the molecular mechanisms underlying disease pathology and the role of nutrition in disease prevention. More specifically, his group is investigating into the role of deregulated apoptosis and epigenetic pathways as key molecular targets underlining the pathological basis of human disease including cancer.

Mihalis is leading a research group which conducts research on the molecular mechanisms underlying disease pathology and the role of nutrition in disease prevention. More specifically, his group is investigating into the role of deregulated apoptosis and epigenetic pathways as key molecular targets underlining the pathological basis of human disease including cancer.

In addition, his group utilizes genomic approaches in an attempt to identify critical genes that act as potential biomarkers of therapeutic outcome. Finally, his group investigates how natural products exert a wide range of biological and pharmacological activities and thus are considered to be of great benefit in maintaining health and preventing disease development.

Mihalis is interested in linking the gap between industry and academia around the areas of bio-economy and industrial biotechnology. For this reason, he is leading research efforts in the multidisciplinary research theme of “Bio-economy” with emphasis on human health. To these ends, he is seeking industrial and academic collaborations for major and substantial funding opportunities.

Linkedin

Marisurf

Campus Address

Ellison Building, A516

Newcastle upon Tyne
NE1 8ST

0191 227 4503

Current and Recent Projects

  • Horizon 2020 Research & Innovation (RIA) Action: “Novel, sustainable marine bio-surfactants/ bio-emulsifiers for commercial exploitation (MARISURF)”, European Commission; 2015-2020; Role: Project Coordinator (09/2015-01/2017) & Principal Investigator
  • Undergraduate Vacation Scholarship Program: “Novel insights of hyperthermia-induced effectiveness of Braf-targeted therapy in malignant melanoma”, Medical Research Scotland; 2016; Role: Principal Investigator
  • Research Program “THALIS”: “Multilevel assessment on biological effects of radiofrequency electromagnetic waves”, Hellenic Ministry of Education, Greece; 2012-2015; Role: Co-Investigator
  • Research Program “SYNERGASIA II”: “Novel functional foods containing bioactive essential oils from Greek endemic species with health promoting properties”, Hellenic Ministry of Education, Greece; 2013-2015; Role: Co-Investigator
  • Research Program “Greece-China Bilateral R&D Cooperation”: “Bee-based natural products as potential cosmeceutical agents with health-promoting properties against UV-induced skin photo-ageing”, Hellenic Ministry of Education, Greece; 2013-2015; Role: Co-Investigator
  • The Recycling Innovation Fund: “Innovative eco-brick/bloc re-using recycled waste from construction”, Zero Waste Scotland, UK; 2014-2015; Role: Co-Investigator
  • Marie Curie International Reintegration Grant (Award # 249315): “Epigenetic deregulation of apoptotic gene expression in hepatocellular carcinoma”, European Commission; 2011-2013; Role: Principal Investigator
  • Innovation Voucher Scheme AY: “New sustainable end market for recycled gypsum in eco-earth-construction”; Zero Waste Scotland, UK; 2013; Role: Co-Investigator

Further Information

Invited Presentations:

  • “Hyperthermia: Turning the heat on cancer”, Public Lecture Series, Northumbria University, 2017, Newcastle Upon Tyne, UK

  • “Bilateral research and teaching opportunities”, Zhengzhou University of Light Industry, 2016, Zhengzhou, Henan Province, REPUBLIC OF CHINA

  • “Turn the heat on malignant melanoma: Therapeutic effectiveness of hyperthermia”, Plenary Lecture International Conference “Science in Technology”, 2015, Athens, GREECE

  • “Isothiocyanates in malignant melanoma chemoprevention”, 3rd Anticancer Agent Development Congress, 2015, Izmir, TURKEY

  • “Therapeutic effectiveness of hyperthermia in human malignant melanoma”, 9th International Conference of Anticancer Research, 2014, Sithonia, GREECE

  • “Turn the heat on cancer”, Inaugural Lecture, Heriot Watt University, 2014, Edinburgh, UK

  • “Natural products and their health-promoting properties in research and development”, School of Life Sciences, Heriot Watt University, 2012, Edinburgh, UK

  • “The role of natural product compounds in human carcinogenesis”, Department of Pharmacology & Toxicology, Otago University, 2011, Dunedin, NEW ZEALAND

  • “Environmental exposure and human carcinogenesis: The role of molecular epidemiology in biomarker development”, Department of Agricultural Development, Democritus University of Thrace, 2009, Orestiada, GREECE

  • “On the journey from oxidative stress to DNA methylation to carcinogenesis: Would S-adenosylmethionine please stand up?”, Graduate Program in Environmental Sciences, University of Nevada, 2008, Reno, USA

  • “Metabolism of DNA methylation in oxidative stress: Implications in carcinogenesis”, School of Public Health, University of Nevada, 2007, Reno, USA

  • “S-adenosylmethionine and oxidative stress: From DNA methylation to carcinogenesis”, Department of Environmental Health Sciences, University of Alabama, 2007, Birmingham, USA

  • “The biochemical basis of DNA methylation in oxidative stress”, Department of Chemistry & Biochemistry, University of Alaska, 2007, Fairbanks, USA

  • “The response of the methionine metabolic cycle in lung epithelial cells exposed to hyperoxia”, Department of Toxicology & Pharmacology, School of Medicine, Indiana University, 2007, Indiana, USA

  • “The transmethylation pathway response in oxidative stress”, Carcinogenesis Division, National Cancer Centre Research Institute, 2006, Tokyo, JAPAN 

Conference Committees & Chair Sessions:

  • Member of the International Organizing Committee, 2nd Anticancer Agents Congress: Targeting Cancer Stem Cell, 2013, Antalya, TURKEY

  • Chair Sessions on “Clinical Chemotherapy”, “Apoptosis”, “New Anticancer Agents”, 9th International Conference of Anticancer Research, 2014, Sithonia, GREECE

  • Member of the International Scientific Committee on Food Science & Technology, International Conference “Science in Technology”, 2015, Athens, GREECE

  • Member of the Organizing & Scientific Committees, 3rd Anticancer Agent Development Congress, 2015, Izmir, TURKEY

  • Chair Session on “Metabolic Targets”, 3rd Anticancer Agent Development Congress, 2015, Izmir, TURKEY

  • Member of the Scientific Committee, 1st International Multidisciplinary Conference on Nutraceuticals and Functional Foods, 2016, Kalamata, GREECE

Key Publications and Outputs

  • Spyridopoulou K, Tiptiri-Kourpeti A, Lampri E, Fitsiou E, Vasileiadis S, Vamvakias M, Bardouki H, Goussia A, Malamou-Mitsi V, Panayiotidis MI, Galanis A, Pappa A, Chlichlia K. Dietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models. Sci Rep, 7(1): 3782, 2017

  • Anestopoulos I, Sfakianos AP, Chlichlia K, Franco R, Panayiotidis MI, Kroll DJ, Pappa A. A novel role of silibinin as a putative epigenetic modulator in human prostate carcinoma. Molecules, 2016: 22(1): 62

  • Mantso T, Sfakianos A, Atkinson A, Anestopoulos I, Mitsiogianni M, Botaitis S, Perente S, Simopoulos C, Vasileiadis S, Franco R, Pappa A, Panayiotidis MI. Development of a novel experimental in vitro model of isothiocyanate-induced apoptosis in human malignant melanoma (A375) cells.  Anticancer Res, 36(12): 6303-6309, 2016

  • Anestopoulos I, Voulgaridou GP, Georgakilas AG, Franco R, Pappa A, Panayiotidis MI. Epigenetic therapy as a novel approach in hepatocellular carcinoma. Pharmacol Ther 145: 103-119, 2015

  • Anestopoulos I, Kavo A, Tentes I, Kortsaris A, Panayiotidis MI, Lazou A, Pappa A. Silibinin protects cardiac myocytes from oxidative stress and inhibits cardiac hypertrophy in vitro: Potential mechanisms. J Nutr Biochem, 24(3): 586-94, 2013

  • Panayiotidis M, Franco R, Bortner CD, Cidlowski JA. Ouabain-induced perturbations in intracellular ionic homeostasis regulate death-receptor-mediated apoptosis. Apoptosis, 15(7): 834-49, 2010

To view my full list of publications record please click here.

PGR Supervisions

  • Vasiliki Lolou, “Skin anti-aging properties induced by isothiocyanates derived from waste sources of cruciferous vegetables”, Department of Applied Sciences, Faculty of Health & Life Sciences, Northumbria University, UK (2017-2020) – Principal Supervisor

  • Melina Mitsiogianni, “Mechanistic insights into the role of isothiocyanates in malignant melanoma chemoprevention”, Department of Applied Sciences, Faculty of Health & Life Sciences, Northumbria University, UK (2016-2019) – Principal Supervisor

  • Theodora Mantso, “Mechanisms of hyperthermia-induced therapeutic effectiveness in malignant melanoma”, School of Life Sciences, Heriot Watt University, UK (2013-2017) – Principal Supervisor

Professional Activity

GRANTS ASSESSOR/REVIEWER:

  • Grant Assessor, British Council, “Newton Funds Institutional Links” and “Institutional Links UK-Gulf”, UK

  • External Expert & Rapporteur, COST-Action, Brussels, EUROPEAN UNION

  • Grant Assessor & Panel Member, Portuguese Foundation for Science and Technology (Fundação para a Ciência e a Tecnologia) – FCT, PORTUGAL

  • Grant Assessor, JSC “National Centre of Science and Technology Evaluation”, REPUBLIC OF KAZAKHSTAN

  • Grant Assessor, Children’s Hospital Research Institute of Manitoba, CANADA

  • Grant Assessor, WHRI-ACADEMY (COFUND Marie Curie action) Fellowship Program, UK

  • Grant Assessor, Wellcome Trust / DBT India Alliance Biomedical Research Fellowship Program for India, UK

  • Grant Assessor, Wellcome Trust / Massachusetts Institute of Technology Postdoctoral Fellowship Program, UK

  • Grant Assessor, French National Alliance for Life & Health Sciences (AVIESAN) jointly with the French National Cancer and the French National Alliance Institute (INCa), FRANCE

  • Reviewer, Ministry of Education, State Scholarships Foundation, Athens, GREECE

  • Grant Assessor & Panel Member, Ministry of Development, General Secretariat for Research & Technology under the program on “Supporting New Enterprises in Research & Technological Development with Emphasis on Agriculture, Fisheries, Foods & Biotechnology”, Athens, GREECE

EDITORIAL POSTS:

Editor-in-Chief:

  • Journal of Nutritional Health & Food Science

  • American Journal of Food & Nutrition

  • Webmed Central Plus-Speciality Nutrition

Associate Editor:

  • Pharmacology & Therapeutics

 Academic Editor:

  • Medicine

Editorial Board Member:

  • Cancer Letters

  • International Journal of Experimental Pathology

  • Toxicology Mechanisms & Methods

  • Pharmacologia

  • World Journal of Respirology

  • Journal of Toxicology & Health

  • Journal of Nutritional Health & Food Engineering

  • Journal of Pharmacology & Toxicology Research

  • International Journal of Food & Nutritional Science

  • Annals of Cancer Research

  • Journal of Disease Markers

  • Austin Journal of Gastrointestinal Cancer: Research & Therapy

Qualifications

  • PhD (2004), School of Pharmacy, University of Colorado, Denver, Colorado, USA

  • MSc (1998), Department of Molecular & Cell Biology, University of Aberdeen, Scotland, UK

  • BSc (1993), Department of Molecular & Cell Biology, University of Aberdeen, Scotland, UK

Research Themes and Scholarly Interests

  • Mihalis is leading a research group which conducts research on the mechanisms underlying disease pathophysiology and the role of nutrition in disease prevention. More specifically, his group is investigating into the role of deregulated apoptotic and epigenetic pathways as key molecular targets underlining the pathophysiology of human disease development including cancer. His group utilizes genomic approaches to identify critical genes that could potentially act as therapeutic biomarkers while it is also investigating how natural products exert a wide range of biological activities relevant to maintaining health and preventing disease development.

  • Mihalis is also interested in linking the gap between industry and academia around the multidisciplinary research themes of bio-economy and industrial biotechnology by leading research efforts relevant to human health. To these ends, he is seeking industrial and academic collaborations aiming for major translational research and substantial funding opportunities.

Sponsors and Collaborators

FUNDING AGENCIES:

  • EUROPEAN COMMISSION

  • HELLENIC MINISTRY OF EDUCATION, GREECE

  • MEDICAL RESEARCH SCOTLAND, UK

  • ZERO WASTE SCOTLAND, UK

  • ALLIANCE WITH THE WASHOE COUNTY MEDICAL SOCIETY, USA

  • AMERICAN INSTITUTE OF CANCER RESEARCH & WORLD CANCER RESEARCH FUND, USA

  • COLORADO TOBACCO RESEARCH PROGMAMME, USA

  • NUTRICIA RESEARCH FOUNDATION, THE NETHERLANDS

COLLABORATORS:

Academic:

  • DEMOCRITUS UNIVERSITY OF THRACE, GREECE

  • NATIONAL TECHNICAL UNIVERSITY OF ATHENS, GREECE

  • UNIVERSITY OF PATRAS, GREECE

  • UNIVERSITY OF IOANNINA, GREECE

  • HERIOT WATT UNIVERSITY, UK

  • ULSTER UNIVERSITY, UK

  • UNIVERSITY OF NEBRASKA-LINCOLN, USA

  • DALHOUSIE UNIVERSITY, CANADA

R&D:

  • NOVA-INSTITUT FUR POLITISCHE UND OKOLOGISCHE INNOVATION GMBH, GERMANY

  • ACONDICIONAMIENTO TARRASSENSE ASSOCIATION, SPAIN

  • NATIONAL HELLENIC RESEARCH FOUNDATION, GREECE

Industrial:

  • APIVITA SA, GREECE

  • NANOIMMUNOTECH SL, SPAIN

  • ECOTECHSYSTEMS SRL, ITALY

  • BIOBASE EUROPE PILOT PLANT VZW, BELGIUM

  • MARLOW FOODS, UK

  • MACPHIE OF GLENBERVIE LTD, UK


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