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Dr Ed Schwalbe

Associate Professor

Department: Applied Sciences

Ed Schwalbe Staffprofile Northumbriauniversity255

Ed began his career with a BSc in Genetics from Leicester University. After working for several years in research labs focussed on medical and human genetics, Ed completed a Master's degree in Bioinformatics, again at Leicester University. After becoming interested in the analysis of large biological datasets during this course, he subsequently moved to Newcastle University to study for a PhD in cancer genomics in Professor Steve Clifford's lab, where his project investigated the molecular sub-classification of the childhood brain tumour, medulloblastoma, using genetic and epigenetic techniques.

After finishing the PhD, he continued working at Newcastle University as a postdoc, where his primary research role involved the continuation of work that arising from his PhD and undertaking collaborative research with investigators based at Bonn University and Malawi.

In October 2013, Ed moved to Northumbria as a Senior Lecturer in Bioinformatics and Biostatistics. Since then, he has continued to investigate childhood cancers, aiming at helping translate biological insights into clinically meaningful tests, and has extensive experience in the analysis of complex biological datasets.

Campus Address

Northumberland Building 447


  • Biological Sciences PhD January 14 2012
  • Information not provided British Association for Cancer Research (BACR) 2013

Key Publications

  • Please visit the Pure Research Information Portal for further information
  • Challenges of starting treatment protocols for acute lymphoblastic leukaemia in a low-income setting — the Blantyre experience, Chagaluka, G., Schwalbe, E., Chakumatha, E., Carey, P., O’Brien, S., Moorman, A., Barretta, E., Rogers, E., Dunsmure, A., Israels, T., Molyneux, E., Bailey, S. 1 Nov 2020, In: British Journal of Haematology
  • Effects of the growth pattern of medulloblastoma on short-term neurological impairments after surgery: results from the prospective multicenter HIT-SIOP PNET 4 study., Schepke, E., Tisell, M., Kennedy, C., Puget, S., Ferroli, P., Chevignard, M., Doz, F., Pizer, B., Rutkowski, S., Massimino, M., Navajas, A., Schwalbe, E., Hicks, D., Clifford, S., Pietsch, T., Lannering, B. Apr 2020, In: Journal of Neurosurgery: Pediatrics
  • Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity, Grabovska, Y., Mackay, A., O’Hare, P., Crosier, S., Finetti, M., Schwalbe, E., Pickles, J., Fairchild, A., Avery, A., Cockle, J., Hill, R., Lindsey, J., Hicks, D., Kristiansen, M., Chalker, J., Anderson, J., Hargrave, D., Jacques, T., Straathof, K., Bailey, S., Jones, C., Clifford, S., Williamson, D. 1 Dec 2020, In: Nature Communications
  • The molecular landscape and associated clinical experience in infant medulloblastoma, Hicks, D., Rafiee, G., Schwalbe, E., Howell, C., Lindsey, J., Hill, R., Smith, A., Adidharma, P., Steel, C., Richardson, S., Pease, L., Danilenko, M., Crosier, S., Joshi, A., Wharton, S., Jacques, T., Pizer, B., Michalski, A., Williamson, D., Bailey, S., Clifford, S. 1 Sep 2020, In: Neuropathology and Applied Neurobiology
  • Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy, Hill, R., Richardson, S., Schwalbe, E., Hicks, D., Lindsey, J., Crosier, S., Rafiee, G., Grabovska, Y., Wharton, S., Jacques, T., Michalski, A., Joshi, A., Pizer, B., Williamson, D., Bailey, S., Clifford, S. 1 Dec 2020, In: The Lancet Child and Adolescent Health
  • Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome, Davies, H., Hodgson, K., Schwalbe, E., Coxhead, J., Sinclair, N., Zou, X., Cockell, S., Husain, A., Nik-Zainal, S., Rajan, N. 7 Oct 2019, In: Nature Communications
  • Imaging characteristics of wingless pathway subgroup medulloblastomas: results from the German HIT/SIOP-trial cohort, Stock, A., Myranek, M., Pietsch, T., Pfister, S., Clifford, S., Goschzik, T., Sturm, D., Schwalbe, E., Hicks, D., Rutkowski, S., Bison, B., Pham, M., Warmuth-Metz, M. 1 Nov 2019, In: American Journal of Neuroradiology
  • Predicting oligonucleotide therapeutic efficacy at the population level, Theotokis, P., Usher, L., Kortschak, C., Schwalbe, E., Moschos, S. 1 Nov 2019, In: Hellenic Journal of Nuclear Medicine
  • Second-generation molecular subgrouping of medulloblastoma, Sharma, T., Schwalbe, E., Williamson, D., Sill, M., Hovestadt, V., Mynarek, M., Rutkowski, S., Robinson, G., Gajjar, A., Cavalli, F., Ramaswamy, V., Taylor, M., Lindsey, J., Hill, R., Jäger, N., Korshunov, A., Hicks, D., Bailey, S., Kool, M., Chavez, L., Northcott, P., Pfister, S., Clifford, S. 1 Aug 2019, In: Acta Neuropathologica
  • SH2B3 inactivation through CN-LOH 12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain, Sinclair, P., Ryan, S., Bashton, M., Hollern, S., Hanna, R., Case, M., Schwalbe, E., Schwab, C., Cranston, R., Young, B., Irving, J., Vora, A., Moorman, A., Harrison, C. Aug 2019, In: Leukemia

PGR Supervision

  • Alice Iliasova Investigation of the molecular and clinical heterogeneity of medulloblastoma subgroups Start: 01/10/2014
  • Dean Thompson Start: 01/10/2018

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