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Dr Tatyana Karabencheva-Christova

Dr Tatyana Karabencheva-Christova is a Lecturer and Marie Curie Career Development Fellow in the Department of Biomedical Sciences.  She graduated in Biology and Chemistry from Sofia University ‘Saint Kliment Ohridski’, Sofia, Bulgaria and attained a PhD degree in Computational Biochemistry from Bristol University.

Tatyana’s research interests are in the field of bimolecular computational science and in particular investigating reaction mechanisms of enzymes, conformational dynamics of proteins and protein-ligand interactions. Currently she is investigating the reaction mechanisms of mono- and binuclear copper-containing enzymes by integrating state of the art computational and the most advanced spectroscopic methods. She carries out this project co-working with Prof Edward Solomon in Stanford University, Stanford, CA, USA.  

Research Funding

Marie Curie International Outgoing Fellowship for Career Development Stanford University ‘Binuclear Non-Coupled Copper Enzymes: An Integrated Computational/ Spectroscopic Study’ (24 months) and Northumbria University (12 months) 245.579€ start date March 2011

National Grid Service UK Grant for supercomputer resources on ‘Modelling Anaplastic Lymphoma Kinase- Inhibitor Interactions’ (2010) 100000 cpu hours

EMBO Fellowship (3 months during 2009) Modelling structure-function relationships of G protein-coupled receptor kinase 2 for Laboratory of Systems Pharmacology and Bioinformatics at Autonomous University of Barcelona, Barcelona, Spain

High-Performance Computing - Europe Fellowships (three grants 5 months during 2009-2010) for visiting Barcelona Supercomputer Centre and the Laboratory of Systems Pharmacology and Bioinformatics at Autonomous University of Barcelona

UK Overseas Postgraduate Scholarship 2005-2009

University of Bristol Postgraduate Scholarship 2005-2009

Project MU-X-1202/2002: “QM/MM Modelling of the enzyme mechanisms of -lactamases”, supported by Bulgarian Science Foundation, 2002-2004.

Selected Publications

Christo Christov, Patricia González-Bulnes, Fanny Malhaire, Tatyana Karabencheva, Cyril Goudet, Jean-Philippe Pin, Amadeu Llebaria and Jesús Giraldo (2011), Integrated Synthetic, Pharmacological and Computational Investigation ofcis 2 (3,5 dichlorophenylcarbamoyl) cyclohexane carboxylic acid enantiomers as Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 4, ChemMedChem, 6, 1, 131-140 DOI: 10.1002/cmdc. 201000378

T Karabencheva and C. Christov, (2010), Mechanisms of Protein Circular Dichroism: Insights from Computational Modelling, Invited review article Advances in Protein Chemistry and Structural Biology, 80, 85-115

T. Karabencheva, R. Donev, Kia Balali-Mood and C. Christov (2010) Individual Contributions of the Aromatic Chromophores to the Near-UV Circular Dichroism in Class A β-lactamases: A Comparative Computational Analysis. Accepted in Biophysical Chemistry151 (1-2): 39-45, DOI: 10.1016/ j.bpc.2010.05.003

C. Christov and T. Karabencheva (2010) Computational Insight in Protein Circular Dichroism: Detailed Analysis of Contributions of Individual Chromophores in TEM-1 ß-Lactamase Accepted in Theoretical Chemistry Accounts

C Christov, T. Karabencheva and A. Lodola (2008) Aromatic Rotational Strengths and Environmental Effects in enzymes: An Electronic Structural Study on β-Lactamases from Class A. Chemical Physics Letters 456, 89-95, doi:10.1016/j.cplett.2008.03.012

C. Christov, T. Karabencheva and A. Lodola (2006) Relationship between chiroptical properties, conformational changes and interactions in enzymes: Computational study on β-lactamases from class A. Computational Biology and Chemistry 32, 167-175, doi:10.1016/j.compbiolchem.2008.02.007

For a full list of publications, please click here.