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Key Publications

  • Please visit the Pure Research Information Portal for further information
  • Transcriptional Terminators Allow Leak-Free Chromosomal Integration of Genetic Constructs in Cyanobacteria, Kelly, C., Taylor, G., Heap, J., Dekker, L., Satsuke, A. 16 Aug 2019, In: Microorganisms
  • A Rhamnose-Inducible System for Precise and Temporal Control of Gene Expression in Cyanobacteria, Kelly, C., Taylor, G., Hitchcock, A., Torres-Méndez, A., Heap, J. 20 Apr 2018, In: ACS Synthetic Biology
  • Review of NAD(P)H-dependent oxidoreductases, Sellés Vidal, L., Kelly, C., Mordaka, P., Heap, J. Feb 2018, In: Biochimica et Biophysica Acta - Proteins and Proteomics
  • Synthetic negative feedback circuits using engineered small RNAs, Kelly, C., Harris, A., Steel, H., Hancock, E., Heap, J., Papachristodoulou, A. 12 Oct 2018, In: Nucleic Acids Research
  • The Autorepressor: a Case Study of the Importance of Model Selection, Harris, A., Kelly, C., Steel, H., Papachristodoulou, A. 23 Jan 2018
  • Expanding the substrates for a bacterial hydrogenlyase reaction, Lamont, C., Kelly, C., Pinske, C., Buchanan, G., Palmer, T., Sargent, F. 10 May 2017, In: Microbiology
  • Synthetic Chemical Inducers and Genetic Decoupling Enable Orthogonal Control of the rhaBAD Promoter, Kelly, C., Liu, Z., Yoshihara, A., Jenkinson, S., Wormald, M., Otero, J., Estévez, A., Kato, A., Marqvorsen, M., Fleet, G., Estévez, R., Izumori, K., Heap, J. 21 Oct 2016, In: ACS Synthetic Biology
  • Integration of an [FeFe]-hydrogenase into the anaerobic metabolism of Escherichia coli, Kelly, C., Pinske, C., Murphy, B., Parkin, A., Armstrong, F., Palmer, T., Sargent, F. 1 Dec 2015, In: Biotechnology Reports


Molecular Biology PhD December 07 2013

Research Themes and Scholarly Interests

Overall Research Interests:

My aim is to be a leader in harnessing the enormous power of Synthetic Biology approaches and technologies to tackle the many enormous crises facing the planet. I believe that we are now on the cusp of developing biotechnologies that can solve issues such as food and energy provision for a growing global population, and the related problems of unsustainable production and use of fertilisers, and catastrophic greenhouse gas emissions. It is my vision and goal to contribute to a sustainable industrial revolution, where waste is viewed as a valuable commodity, and thus converted through synthetic biology, into value products at high yields and in commercially-attractive processes.

Specific Projects:

  1. I'm interested in constructing synthetic regulation so that we can reliably engineer complex metabolic pathways in industrially-relevant organsms to enable sustainable production of high-value chemicals.
  2. I'm also interested in using small bacterial RNAs (sRNAs) as both synthetic biology tools and as novel antimicrobial therapeutics.


I am very keen to collaborate with companies on ways to engineer organisms for the reliable scaling-up of bioproduction, as well as companies interested in developing novel antimicrobial approaches using Synthetic Biology. Please get in touch at

Students and Visiting Researchers:

I am always open to hosting undergraduate students for summer placements and visiting researchers for short-term collaborative projects. Studentships are available that we can apply for to host you, but please get in touch as early as possible. Please get in touch at

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