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Dr Darren Smith

Associate Professor

Department: Applied Sciences

Dr Smith is an Associate Professor in Bacteriophage Biology within the Department of Applied Biology, Cellular and Molecular Sciences/Microbiology Group. He graduated from the University of Liverpool with a BSc in Microbiology in 2000. After a 1.5 years working for Applied Biosystems he spent the following 7.5 years completing both a PhD (2005) and Post-Doctoral research in the laboratory of Alan McCarthy, Heather Allison and Jon Saunders studying the biology of Shiga toxin encoding bacteriophages.

 Prior to joining Northumbria University, Dr Smith completed his postdoctoral research in Professor Andrew Owen’s group, Liverpool HIV pharmacology group, University of Liverpool, in collaboration with Professor Steve Rannard’s group studying the impact of nanoformulation on highly active antiretroviral therapy drugs used in the treatment of HIV infection.   These studies have included drug delivery, cellular accumulation and transcellular permeability models.

Darren Smith

Qualifications

  • Microbiology PhD June 30 2005
  • Fellow (FHEA) Higher Education Academy (HEA) 2014
  • Information not provided Society for General Microbiology (SGM) 2011

Key Publications

  • Please visit the Pure Research Information Portal for further information
  • Temperate bacteriophages from chronic Pseudomonas aeruginosa lung infections show disease-specific changes in host range and modulate antimicrobial susceptibility, Tariq, M., Everest, F., Cowley, L., Wright, R., Holt, G., Ingram, H., Duignan, L., Nelson, A., Lanyon, C., Perry, A., Perry, J., Bourke, S., Brockhurst, M., Bridge, S., de Soyza, A., Smith, D. 4 Jun 2019, In: mSystems
  • Genome-based classification of micromonosporae with a focus on their biotechnological and ecological potential, Carro, L., Nouioui, I., Sangal, V., Meier-kolthoff, J., Trujillo, M., Montero-calasanz, M., Sahin, N., Smith, D., Kim, K., Peluso, P., Deshpande, S., Woyke, T., Shapiro, N., Kyrpides, N., Klenk, H., Göker, M., Goodfellow, M. 1 Dec 2018, In: Scientific Reports
  • The involvement of the low-oxygen-activated locus of Burkholderia cenocepacia in adaptation during cystic fibrosis infection, Cullen, L., O’connor, A., Mccormack, S., Owens, R., Holt, G., Collins, C., Callaghan, M., Doyle, S., Smith, D., Schaffer, K., Fitzpatrick, D., Mcclean, S. 6 Sep 2018, In: Scientific Reports
  • The effect of the timing of exposure to Campylobacter jejuni on the gut microbiome and inflammatory responses of broiler chickens, Connerton, P., Richards, P., Lafontaine, G., O’kane, P., Ghaffar, N., Cummings, N., Smith, D., Fish, N., Connerton, I. 12 May 2018, In: Microbiome
  • Virulence factors of Moraxella catarrhalis outer membrane vesicles are major targets for cross-reactive antibodies and have adapted during evolution, Augustyniak, D., Seredyński, R., Mcclean, S., Roszkowiak, J., Roszniowski, B., Smith, D., Drulis-kawa, Z., Mackiewicz, P. 21 Mar 2018, In: Scientific Reports
  • Genomic analysis of endemic clones of toxigenic and non-toxigenic Corynebacterium diphtheriae in Belarus during and after the major epidemic in 1990s, Grosse-kock, S., Kolodkina, V., Schwalbe, E., Blom, J., Burkovski, A., Hoskisson, P., Brisse, S., Smith, D., Sutcliffe, I., Titov, L., Sangal, V. 13 Nov 2017, In: BMC Genomics
  • Reducing Viability Bias in Analysis of Gut Microbiota in Preterm Infants at Risk of NEC and Sepsis, Young, G., Smith, D., Embleton, N., Berrington, J., Schwalbe, E., Cummings, S., van der Gast, C., Lanyon, C. 6 Jun 2017, In: Frontiers in cellular and infection microbiology
  • Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis, Scalacci, N., Brown, A., Pavan, F., Ribeiro, C., Manetti, F., Bhakta, S., Maitra, A., Smith, D., Petricci, E., Castagnolo, D. 15 Feb 2017, In: European Journal of Medicinal Chemistry
  • Shigatoxin encoding Bacteriophage φ24B modulates bacterial metabolism to raise antimicrobial tolerance, Holt, G., Lodge, J., McCarthy, A., Graham, A., Young, G., Bridge, S., Brown, A., Veses-Garcia, M., Lanyon, C., Sails, A., Allison, H., Smith, D. 20 Jan 2017, In: Scientific Reports
  • Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies, Giardiello, M., Liptrott, N., McDonald, T., Moss, D., Siccardi, M., Martin, P., Smith, D., Gurjar, R., Rannard, S., Owen, A. 21 Oct 2016, In: Nature Communications

PGR Supervision

  • Giles Holt Characterising the impact on bacterial physiology of phage infection and phage as a tool to support microbiota studies Start: 01/11/2013
  • Liberty Duignan Start: 01/10/2016

Research Themes and Scholarly Interests

Dr Smith’s research interests relate to how bacteriophages alter bacterial physiology, phenotype and bacterial community structure through chromosomal integration, subversion of cell function, or during active infection and cell lysis.  His group uses lab, multi-omic and bioinformatics based approaches to determine the physiological impact of lysogeny or lytic infection on the host bacterium and the surrounding microbiota in clinical and environmental settings.  His groups research aims are to offer an insight into the modulation of microbial communities and how phages play a role in bacterial/community selection and evolution.

All research is heavily linked to genomics, metagenomics, transcriptomics and linked to a range of techniques including; molecular, protein, bioinformatics, microbiological and virological based techniques to study; virus-host interactions; phage genomics; identification of phage encoded genes that provide positive selection for the infected bacterial host and seasonal epidemiology versus virus genotype. 

Dr Smith is the academic lead for the DNA sequencing research facility at Northumbria University, NU-OMICS that is linked to both academic and industrially linked DNA sequencing projects.


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