Skip navigation

Prof Darren Smith

Professor

Department: Applied Sciences

Darren Smith is a Professor of Bacteriophage Biology within the Department of Applied Biology, Cellular and Molecular Sciences/Microbiology Group. He graduated from the University of Liverpool with a BSc in Microbiology in 2000. After a 1.5 years working at Applied Biosystems he spent the following 7.5 years completing both a PhD (2005) and Post-Doctoral research in the laboratory of Alan McCarthy, Heather Allison and Jon Saunders studying the biology of Shiga toxin encoding bacteriophages.

Prior to joining Northumbria University, Dr Smith worked as a postdoctoral research associate with Professor Andrew Owen’s, University of Liverpool HIV pharmacology group in collaboration with Professor Steve Rannard focussing the impact of nanoformulation on highly active antiretroviral therapy drugs used in the treatment of HIV infection.   These studies included drug delivery, cellular accumulation and transcellular gut permeability  models.

Darren Smith

Professor Smith’s research interests relate to how bacteriophages alter bacterial physiology, phenotype and bacterial community structure through chromosomal integration, subversion of cell function, or during active infection and cell lysis.  His group uses lab, multi-omic and bioinformatics based approaches to determine the physiological impact of lysogeny or lytic infection on the host bacterium and the surrounding microbiota in clinical and environmental settings.  His groups research aims are to offer an insight into the modulation of microbial communities and how phages play a role in bacterial/community selection and evolution.

All research is heavily linked to genomics, metagenomics, transcriptomics and linked to a range of techniques including; molecular, protein, bioinformatics, microbiological and virological based techniques to study; virus-host interactions; phage genomics; identification of phage encoded genes that provide positive selection for the infected bacterial host and seasonal epidemiology versus virus genotype. 

Professor Smith is the academic lead and director for the DNA sequencing research facility at Northumbria University, NU-OMICS. This is an outfacing service that is linked to both academic and industrially linked DNA sequencing projects.

  • Please visit the Pure Research Information Portal for further information
  • Combined epidemiological and genomic analysis of nosocomial SARS-CoV-2 infection early in the pandemic and the role of unidentified cases in transmission, Snell, L., Fisher, C., Taj, U., Stirrup, O., Merrick, B., Alcolea-Medina, A., Charalampous, T., Signell, A., Wilson, H., Betancor, G., Kia Ik, M., Cunningham, E., Cliff, P., Pickering, S., Galao, R., Batra, R., Neil, S., Malim, M., Doores, K., Douthwaite, S., Nebbia, G., Edgeworth, J., Awan, A., Bashton, M., Nelson, A., McCann, C., Young, G., Smith, D. 1 Jan 2022, In: Clinical Microbiology and Infection
  • Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study, Nyberg, T., Ferguson, N., Nash, S., Webster, H., Flaxman, S., Andrews, N., Hinsley, W., Bernal, J., Kall, M., Bhatt, S., Blomquist, P., Zaidi, A., Volz, E., Aziz, N., Harman, K., Funk, S., Abbott, S., Lopez Bernal, J., Abdul Aziz, N., Hope, R., Charlett, A., Chand, M., Ghani, A., Seaman, S., Dabrera, G., De Angelis, D., Presanis, A., Thelwall, S., Bashton, M., Smith, D., Nelson, A., Young, G., McCann, C. 2 Apr 2022, In: The Lancet
  • COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study, Kläser, K., Molteni, E., Graham, M., Canas, L., Österdahl, M., Antonelli, M., Chen, L., Deng, J., Murray, B., Kerfoot, E., Wolf, J., May, A., Fox, B., Capdevila, J., Aanensen, D., Abudahab, K., Adams, H., Adams, A., Afifi, S., Aggarwal, D., Ahmad, S., Aigrain, L., Alcolea-Medina, A., Alikhan, N., Allara, E., Amato, R., Angyal, A., Annett, T., Aplin, S., Ariani, C., Asad, H., Ash, A., Ashfield, P., Ashford, F., Atkinson, L., Attwood, S., Auckland, C., Aydin, A., Baker, D., Baker, P., Bashton, M., Crown, M., Hartley, J., Henderson, J., Jones, H., McCann, C., Nelson, A., Smith, D., Yew, W., Young, G., Hollis, A., Stanley, W. 1 Dec 2022, In: Scientific Reports
  • Descriptive comparison of admission characteristics between pandemic waves and multivariable analysis of the association of the Alpha variant (B.1.1.7 lineage) of SARS-CoV-2 with disease severity in inner London, Snell, L., Wang, W., Alcolea-Medina, A., Charalampous, T., Batra, R., De Jongh, L., Higgins, F., Nebbia, G., Wang, Y., Edgeworth, J., Curcin, V., Bashton, M., Smith, D., Crown, M. 8 Feb 2022, In: BMJ Open
  • Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: multicenter, prospective study, Stirrup, O., Blackstone, J., Mapp, F., MacNeil, A., Panca, M., Holmes, A., Machin, N., Shin, G., Mahungu, T., Saeed, K., Saluja, T., Taha, Y., Mahida, N., Pope, C., Chawla, A., Cutino-Moguel, M., Tamuri, A., Williams, R., Darby, A., Robertson, D., Flaviani, F., Nastouli, E., Robson, S., Smith, D., Laing, K., Monahan, I., Kele, B., Haldenby, S., George, R., Bashton, M., Witney, A., Byott, M., Coll, F., Chapman, M., Peacock, S., Hughes, J., Nebbia, G., Partridge, D., Parker, M., Price, J., Peters, C., Roy, S., Snell, L., de Silva, T., Thomson, E., Flowers, P., Copas, A., Breuer, J., McCann, C., Young, G., Nelson, A. 13 Sep 2022, In: eLife
  • Evolution of viral variants in remdesivir‐treated and untreated SARS‐CoV‐2‐infected pediatrics patients, Boshier, F., Pang, J., Penner, J., Parker, M., Alders, N., Bamford, A., Grandjean, L., Grunewald, S., Hatcher, J., Best, T., Dalton, C., Bynoe, P., Frauenfelder, C., Köeglmeier, J., Myerson, P., Roy, S., Williams, R., Silva, T., Goldstein, R., Breuer, J., Allan, J., Bashton, M., Loh, J., Nelson, A., Smith, D., Yew, W., Young, G. 1 Jan 2022, In: Journal of Medical Virology
  • Factors affecting turnaround time of SARS-CoV-2 sequencing for inpatient infection prevention and control decision making: Analysis of data from the COG-UK HOCI study, Colton, H., Parker, M., Stirrup, O., Blackstone, J., Loose, M., McClure, C., Roy, S., Williams, C., McLeod, J., Smith, D., Taha, Y., Zhang, P., Hsu, S., Kele, B., Harris, K., Mapp, F., Williams, R., Flowers, P., Breuer, J., Partridge, D., de Silva, T. 10 Oct 2022, In: Journal of Hospital Infection
  • Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission, Aggarwal, D., Page, A., Schaefer, U., Savva, G., Myers, R., Volz, E., Ellaby, N., Platt, S., Groves, N., Gallagher, E., Tumelty, N., Le Viet, T., Hughes, G., Chen, C., Turner, C., Logan, S., Harrison, A., Peacock, S., Chand, M., Harrison, E., Smith, D., Bashton, M., Young, G., Nelson, A., McCann, C., Yew, W. Dec 2022, In: Nature Communications
  • Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission, Aggarwal, D., Warne, B., Jahun, A., Hamilton, W., Fieldman, T., du Plessis, L., Hill, V., Blane, B., Watkins, E., Wright, E., Hall, G., Ludden, C., Myers, R., Hosmillo, M., Chaudhry, Y., Pinckert, M., Georgana, I., Izuagbe, R., Leek, D., Nsonwu, O., Hughes, G., Packer, S., Page, A., Metaxaki, M., Fuller, S., Weale, G., Holgate, J., Brown, C., Howes, R., McFarlane, D., Dougan, G., Pybus, O., Angelis, D., Maxwell, P., Peacock, S., Weekes, M., Illingworth, C., Harrison, E., Matheson, N., Goodfellow, I., Bashton, M., Smith, D., Young, G., McCann, C., Nelson, A., Yew, W., Jones, H. Dec 2022, In: Nature Communications
  • Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning, Nickbakhsh, S., Hughes, J., Christofidis, N., Griffiths, E., Shaaban, S., Enright, J., Smollett, K., Nomikou, K., Palmalux, N., Tong, L., Carmichael, S., Sreenu, V., Orton, R., Goldstein, E., Tomb, R., Templeton, K., Gunson, R., da Silva Filipe, A., Milosevic, C., Thomson, E., Robertson, D., Holden, M., Illingworth, C., Smith-Palmer , A., Smith, D., Bashton, M., Young, G., McCann, C., Nelson, A., Crown, M., Henderson, J., Yew, W. Dec 2022, In: Scientific Reports

  • Jennifer Le-Anne Coulson Dissecting the role of bacteriophages on bacterial community design and function in the human preterm infant gut. Start Date: 01/10/2022
  • Rui Nunes Dos Santos Isolation and classification of bacteriophages purified from maternal breast milk and determination of their role in bacterial community development. Start Date: 01/10/2022
  • Mariklairi Kiourkou Dissecting the role of bacteriophages on bacterial community design and function in the human preterm infant gut. Start Date: 01/10/2022
  • Theodora Tanou Dissecting the role of bacteriophages on bacterial community design and function in the human preterm infant gut. Start Date: 01/10/2022
  • Onengiye Ogbanga THE FORENSIC MICROBIOME: INVESTIGATION OF THE HUMANMICROBIOME FOR TIME SINCE DEATH ESTIMATIONS AND HUMANIDENTIFICATIONS Start Date: 30/06/2022
  • Liberty Duignan The Temperate Bacteriophages of Pseudomonas aeruginosa and Their Role in Chronic Lung Infection Start Date: 01/10/2016 End Date: 21/01/2022
  • Giles Holt Characterising the impact on bacterial physiology of phage infection and phage as a tool to support microbiota studies Start Date: 01/11/2013 End Date: 07/03/2019
  • Francesca Everest Characterising the Role and Evolution of Temperate Bacteriophages in Chronic Respiratory Infections Including Cystic Fibrosis and Bronchiectasis Start Date: 01/10/2012 End Date: 03/10/2016
  • Mohammad Tariq Characterising Temperate Bacteriophages Isolated from the Microbiota of Chronic Respiratory Disease Start Date: 01/10/2012 End Date: 20/04/2017
  • Saif Abraham Proposal for research into the role of bacteriophages in Pseudomonas aeruginosa infection in chronic respiratory disease Start Date: 01/10/2020 End Date: 23/06/2021

  • Microbiology PhD June 30 2005
  • Fellow (FHEA) Higher Education Academy (HEA) 2014
  • Information not provided Society for General Microbiology (SGM) 2011


a sign in front of a crowd
+

Northumbria Open Days

Open Days are a great way for you to get a feel of the University, the city of Newcastle upon Tyne and the course(s) you are interested in.

Research at Northumbria
+

Research at Northumbria

Research is the life blood of a University and at Northumbria University we pride ourselves on research that makes a difference; research that has application and affects people's lives.

a person sitting at a table
+

Order your prospectus

If you would like to know more about our courses, or life in general as a student at Northumbria, then we can help you.

Latest News and Features

International Volunteer Day 2022
Hon Grad Roma Agrawal
Hon Grad Paul Blake
Tom Harrison
Dr Cook at Camp Nou
Stephanie L. Young pictured in a lecture theatre smiling at the camera
More news
More events

Upcoming events

Northumbria University Carol Service
SAFECONOMY- Solar to Alternative Fuel Economy Workshop
-
Childhood, Care and Coronavirus Conference

Back to top