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Prof Darren Smith

Professor

Department: Applied Sciences

Dr Smith is an Associate Professor in Bacteriophage Biology within the Department of Applied Biology, Cellular and Molecular Sciences/Microbiology Group. He graduated from the University of Liverpool with a BSc in Microbiology in 2000. After a 1.5 years working for Applied Biosystems he spent the following 7.5 years completing both a PhD (2005) and Post-Doctoral research in the laboratory of Alan McCarthy, Heather Allison and Jon Saunders studying the biology of Shiga toxin encoding bacteriophages.

 Prior to joining Northumbria University, Dr Smith completed his postdoctoral research in Professor Andrew Owen’s group, Liverpool HIV pharmacology group, University of Liverpool, in collaboration with Professor Steve Rannard’s group studying the impact of nanoformulation on highly active antiretroviral therapy drugs used in the treatment of HIV infection.   These studies have included drug delivery, cellular accumulation and transcellular permeability models.

Darren Smith

Research Themes and Scholarly Interests

Dr Smith’s research interests relate to how bacteriophages alter bacterial physiology, phenotype and bacterial community structure through chromosomal integration, subversion of cell function, or during active infection and cell lysis.  His group uses lab, multi-omic and bioinformatics based approaches to determine the physiological impact of lysogeny or lytic infection on the host bacterium and the surrounding microbiota in clinical and environmental settings.  His groups research aims are to offer an insight into the modulation of microbial communities and how phages play a role in bacterial/community selection and evolution.

All research is heavily linked to genomics, metagenomics, transcriptomics and linked to a range of techniques including; molecular, protein, bioinformatics, microbiological and virological based techniques to study; virus-host interactions; phage genomics; identification of phage encoded genes that provide positive selection for the infected bacterial host and seasonal epidemiology versus virus genotype. 

Dr Smith is the academic lead for the DNA sequencing research facility at Northumbria University, NU-OMICS that is linked to both academic and industrially linked DNA sequencing projects.

Key Publications

  • Please visit the Pure Research Information Portal for further information
  • Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study, Graham, M., Sudre, C., May, A., Antonelli, M., Murray, B., Varsavsky, T., Kläser, K., Canas, L., Molteni, E., Modat, M., Drew, D., Nguyen, L., Polidori, L., Selvachandran, S., Hu, C., Capdevila, J., Hammers, A., Chan, A., Wolf, J., Spector, T., Steves, C., Ourselin, S., Koshy, C., Ash, A., Wise, E., Moore, N., Mori, M., Cortes, N., Lynch, J., Kidd, S., Fairley, D., Curran, T., McKenna, J., Adams, H., Fraser, C., Golubchik, T., Bonsall, D., Hassan-Ibrahim, M., Malone, C., Cogger, B., Wantoch, M., Reynolds, N., Warne, B., Smith, D., Bashton, M., Young, G., Nelson, A., McCann, C., Yew, W., Jones, H. 1 May 2021, In: The Lancet Public Health
  • Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity, Thomson, E., Rosen, L., Shepherd, J., Spreafico, R., da Silva Filipe, A., Wojcechowskyj, J., Davis, C., Piccoli, L., Pascall, D., Dillen, J., Lytras, S., Czudnochowski, N., Shah, R., Meury, M., Jesudason, N., De Marco, A., Li, K., Bassi, J., O'Toole, A., Pinto, D., Colquhoun, R., Culap, K., Jackson, B., Zatta, F., Rambaut, A., Jaconi, S., Sreenu, V., Nix, J., Zhang, I., Jarrett, R., Glass, W., Beltramello, M., Nomikou, K., Pizzuto, M., Tong, L., Cameroni, E., Croll, T., Johnson, N., Di Iulio, J., Wickenhagen, A., Ceschi, A., Harbison, A., Mair, D., Ferrari, P., Smollett, K., Sallusto, F., Carmichael, S., Garzoni, C., Nichols, J., Galli, M., Robertson, D., Snell, G., Bashton, M., Smith, D., Nelson, A., Young, G. 4 Mar 2021, In: Cell
  • Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial, Emary, K., Golubchik, T., Aley, P., Ariani, C., Angus, B., Bibi, S., Blane, B., Bonsall, D., Cicconi, P., Charlton, S., Clutterbuck, E., Collins, A., Cox, T., Darton, T., Dold, C., Douglas, A., Duncan, C., Ewer, K., Flaxman, A., Faust, S., Ferreira, D., Feng, S., Finn, A., Folegatti, P., Fuskova, M., Galiza, E., Goodman, A., Green, C., Green, C., Greenland, M., Hallis, B., Heath, P., Hay, J., Hill, H., Jenkin, D., Kerridge, S., Lazarus, R., Libri, V., Lillie, P., Ludden, C., Marchevsky, N., Minassian, A., McGregor, A., Mujadidi, Y., Phillips, D., Plested, E., Pollock, K., Robinson, H., Smith, A., Song, R., Bashton, M., Nelson, A., Young, G., Smith, D. 10 Apr 2021, In: The Lancet
  • Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK, Du Plessis, L., Mccrone, J., Zarebski, A., Hill, V., Ruis, C., Gutierrez, B., Raghwani, J., Ashworth, J., Colquhoun, R., Connor, T., Faria, N., Jackson, B., Loman, N., O’toole, Á., Nicholls, S., Parag, K., Scher, E., Vasylyeva, T., Volz, E., Watts, A., Bogoch, I., Khan, K., Aanensen, D., Kraemer, M., Rambaut, A., Pybus, O., Bashton, M., Smith, D., Young, G., Nelson, A. 12 Feb 2021, In: Science
  • Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England, Davies, N., Abbott, S., Barnard, R., Jarvis, C., Kucharski, A., Munday, J., Pearson, C., Russell, T., Tully, D., Washburne, A., Wenseleers, T., Gimma, A., Waites, W., Wong, K., van Zandvoort, K., Silverman, J., Diaz-Ordaz, K., Keogh, R., Eggo, R., Funk, S., Jit, M., Atkins, K., Edmunds, W., Bashton, M., Smith, D., Young, G., Nelson, A. 9 Apr 2021, In: Science
  • Evaluating the effects of SARS-CoV-2 Spike mutation D614G on transmissibility and pathogenicity, Volz, E., Hill, V., McCrone, J., Price, A., Jorgensen, D., O’Toole, Á., Southgate, J., Johnson, R., Jackson, B., Nascimento, F., Rey, S., Nicholls, S., Colquhoun, R., da Silva Filipe, A., Shepherd, J., Pascall, D., Shah, R., Jesudason, N., Li, K., Jarrett, R., Pacchiarini, N., Bull, M., Geidelberg, L., Siveroni, I., Goodfellow, I., Loman, N., Pybus, O., Robertson, D., Thomson, E., Rambaut, A., Connor, T., Bashton, M., Young, G., Smith, D. 7 Jan 2021, In: Cell
  • SARS-CoV-2 evolution during treatment of chronic infection, Kemp, S., Collier, D., Datir, R., Ferreira, I., Gayed, S., Jahun, A., Hosmillo, M., Rees-Spear, C., Mlcochova, P., Lumb, I., Roberts, D., Chandra, A., Temperton, N., Sharrocks, K., Blane, E., Modis, Y., Leigh, K., Briggs, J., van Gils, M., Smith, K., Bradley, J., Smith, C., Doffinger, R., Ceron-Gutierrez, L., Barcenas-Morales, G., Pollock, D., Goldstein, R., Smielewska, A., Skittrall, J., Gouliouris, T., Goodfellow, I., Gkrania-Klotsas, E., Illingworth, C., McCoy, L., Gupta, R., Bashton, M., Nelson, A., Young, G., Smith, D. 8 Apr 2021, In: Nature
  • Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies, Collier, D., De Marco, A., Ferreira, I., Meng, B., Datir, R., Walls, A., Kemp S, S., Bassi, J., Pinto, D., Fregni, C., Bianchi, S., Tortorici, M., Bowen, J., Culap, K., Jaconi, S., Cameroni, E., Snell, G., Pizzuto, M., Pellanda, A., Garzoni, C., Riva, A., Elmer, A., Kingston, N., Graves, B., McCoy, L., Smith, K., Bradley, J., Temperton, N., Lourdes Ceron-Gutierrez, L., Barcenas-Morales, G., Harvey, W., Virgin, H., Lanzavecchia, A., Piccoli, L., Doffinger, R., Wills, M., Veesler, D., Corti, D., Gupta, R., Bashton, M., Young, G., McCann, C., Nelson, A., Smith, D. 6 May 2021, In: Nature
  • Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data, Parker, M., Lindsey, B., Leary, S., Gaudieri, S., Chopra, A., Wyles, M., Angyal, A., Green, L., Parsons, P., Tucker, R., Brown, R., Groves, D., Johnson, K., Carrilero, L., Heffer, J., Partridge, D., Evans, C., Raza, M., Keeley, A., Smith, N., Filipe, A., Shepherd, J., Davis, C., Bennett, S., Sreenu, V., Kohl, A., Aranday-Cortes, E., Tong, L., Nichols, J., Thomson, E., Wang, D., Mallal, S., de Silva, T., Bashton, M., Young, G., Allan, J., Loh, J., Nelson, A., Smith, D., Yew, W. 1 Apr 2021, In: Genome Research
  • The Impact of NOD2 Genetic Variants on the Gut Mycobiota in Crohn’s Disease Patients in Remission and in Individuals Without Gastrointestinal Inflammation, Nelson, A., Stewart, C., Kennedy, N., Lodge, J., Tremelling, M., Probert, C., Parkes, M., Mansfield, J., Smith, D., Hold, G., Lees, C., Bridge, S., Lamb, C. 1 May 2021, In: Journal of Crohn's and Colitis

PGR Supervision

  • Mohammad Tariq Characterising Temperate Bacteriophages Isolated from the Microbiota of Chronic Respiratory Disease Start Date: 01/10/2012 End Date: 20/04/2017
  • Francesca Everest Characterising the Role and Evolution of Temperate Bacteriophages in Chronic Respiratory Infections Including Cystic Fibrosis and Bronchiectasis Start Date: 01/10/2012 End Date: 03/10/2016
  • Saif Abraham Proposal for research into the role of bacteriophages in Pseudomonas aeruginosa infection in chronic respiratory disease Start Date: 01/10/2020
  • Liberty Duignan The Temperate Bacteriophages of Pseudomonas aeruginosa and Their Role in Chronic Lung Infection Start Date: 01/10/2016
  • Giles Holt Characterising the impact on bacterial physiology of phage infection and phage as a tool to support microbiota studies Start Date: 01/11/2013 End Date: 07/03/2019

Qualifications

  • Microbiology PhD June 30 2005
  • Fellow (FHEA) Higher Education Academy (HEA) 2014
  • Information not provided Society for General Microbiology (SGM) 2011


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