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Dr Ed Schwalbe

Associate Professor

Department: Applied Sciences

Ed Schwalbe Staffprofile Northumbriauniversity255

Ed began his career with a BSc in Genetics from Leicester University. After working for several years in research labs focussed on medical and human genetics, Ed completed a Master's degree in Bioinformatics, again at Leicester University. After becoming interested in the analysis of large biological datasets during this course, he subsequently moved to Newcastle University to study for a PhD in cancer genomics in Professor Steve Clifford's lab, where his project investigated the molecular sub-classification of the childhood brain tumour, medulloblastoma, using genetic and epigenetic techniques.

After finishing the PhD, he continued working at Newcastle University as a postdoc, where his primary research role involved the continuation of work that arising from his PhD and undertaking collaborative research with investigators based at Bonn University and Malawi.

In October 2013, Ed moved to Northumbria as a Senior Lecturer in Bioinformatics and Biostatistics. Since then, he has continued to investigate childhood cancers, aiming at helping translate biological insights into clinically meaningful tests, and has extensive experience in the analysis of complex biological datasets.

Campus Address

Northumberland Building 447



Key Publications

  • Please visit the Pure Research Information Portal for further information
  • Advanced molecular pathology for rare tumours: A national feasibility study and model for centralised medulloblastoma diagnostics, Crosier, S., Hicks, D., Schwalbe, E., Williamson, D., Nicholson, S., Smith, A., Lindsey, J., Michalski, A., Pizer, B., Bailey, S., Bown, N., Cuthbert, G., Wharton, S., Jacques, T., Joshi, A., Clifford, S. 7 Apr 2021, In: Neuropathology and Applied Neurobiology
  • Inter and intra-tumoral heterogeneity as a platform for personalized therapies in medulloblastoma, Danilenko, M., Clifford, S., Schwalbe, E. 1 Mar 2021, In: Pharmacology and Therapeutics
  • The Human Bone Proteome Before and After Decomposition: Investigating the effects of Biological Variation and Taphonomic Alteration on Bone Protein Profiles and the Implications for Forensic Proteomics, Mickleburgh, H., Schwalbe, E., Bonicelli, A., Mizukami, H., Sellitto, F., Starace, S., Wescott, D., Carter, D., Procopio, N. 8 Mar 2021, In: Journal of Proteome Research
  • Challenges of starting treatment protocols for acute lymphoblastic leukaemia in a low-income setting — the Blantyre experience, Chagaluka, G., Schwalbe, E., Chakumatha, E., Carey, P., O’Brien, S., Moorman, A., Barretta, E., Rogers, E., Dunsmure, A., Israels, T., Molyneux, E., Bailey, S. 1 Nov 2020, In: British Journal of Haematology
  • Effects of the growth pattern of medulloblastoma on short-term neurological impairments after surgery: results from the prospective multicenter HIT-SIOP PNET 4 study., Schepke, E., Tisell, M., Kennedy, C., Puget, S., Ferroli, P., Chevignard, M., Doz, F., Pizer, B., Rutkowski, S., Massimino, M., Navajas, A., Schwalbe, E., Hicks, D., Clifford, S., Pietsch, T., Lannering, B. Apr 2020, In: Journal of Neurosurgery: Pediatrics
  • Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity, Grabovska, Y., Mackay, A., O’Hare, P., Crosier, S., Finetti, M., Schwalbe, E., Pickles, J., Fairchild, A., Avery, A., Cockle, J., Hill, R., Lindsey, J., Hicks, D., Kristiansen, M., Chalker, J., Anderson, J., Hargrave, D., Jacques, T., Straathof, K., Bailey, S., Jones, C., Clifford, S., Williamson, D. 1 Dec 2020, In: Nature Communications
  • The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second-generation subtypes, Hicks, D., Rafiee, G., Schwalbe, E., Howell, C., Lindsey, J., Hill, R., Smith, A., Adidharma, P., Steel, C., Richardson, S., Pease, L., Danilenko, M., Crosier, S., Joshi, A., Wharton, S., Jacques, T., Pizer, B., Michalski, A., Williamson, D., Bailey, S., Clifford, S. 1 Sep 2020, In: Neuropathology and Applied Neurobiology
  • Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study, Hill, R., Richardson, S., Schwalbe, E., Hicks, D., Lindsey, J., Crosier, S., Rafiee, G., Grabovska, Y., Wharton, S., Jacques, T., Michalski, A., Joshi, A., Pizer, B., Williamson, D., Bailey, S., Clifford, S. 1 Dec 2020, In: The Lancet Child and Adolescent Health
  • Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome, Davies, H., Hodgson, K., Schwalbe, E., Coxhead, J., Sinclair, N., Zou, X., Cockell, S., Husain, A., Nik-Zainal, S., Rajan, N. 7 Oct 2019, In: Nature Communications
  • Imaging characteristics of wingless pathway subgroup medulloblastomas: results from the German HIT/SIOP-trial cohort, Stock, A., Myranek, M., Pietsch, T., Pfister, S., Clifford, S., Goschzik, T., Sturm, D., Schwalbe, E., Hicks, D., Rutkowski, S., Bison, B., Pham, M., Warmuth-Metz, M. 1 Nov 2019, In: American Journal of Neuroradiology

PGR Supervision

  • Alice Iliasova Investigation of the molecular and clinical heterogeneity of medulloblastoma subgroups Start Date: 01/10/2014
  • Dean Thompson Transforming Cancer Molecular Diagnostics: Molecular Subgrouping and Analysis of Medulloblastoma using Whole Genome Bisulfite Sequencing Start Date: 01/10/2018

Qualifications

  • Biological Sciences PhD January 14 2012
  • Information not provided British Association for Cancer Research (BACR) 2013


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