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Dr Lynn Dover

Reader in Microbial Physiology

Department: Applied Sciences

Lynn joined Northumbria in 2007 as a Senior Lecturer in Medical Microbiology contributing to the development of MSc Biotechnology and MSc Microbiology as well as microbiological and biochemical aspects of the undergraduate curriculum in Biomedical Science.

Dr Lynn Dover Staffprofile Northumbriauniversity255Lynn began his biological education at Sunderland Polytechnic graduating with BSc Applied Biology in 1990.  His enduring fascination for microbial pathogenicity, and applied research in general, was sparked by a sandwich placement at the Chemical Defence Establishment, Porton Down.

His doctoral studies at the University of Hull provided the foundation for his current research interests in mycobacteria (and their relatives) and the bacterial acquisition of iron. During his long post-doctoral career he contributed to the understanding of the role of various facets of bacterial physiology and genomics in the establishment and control of infections including meningitis and tuberculosis producing over 50 publications.

Lynn joined Northumbria in 2007 as a Senior Lecturer in Medical Microbiology contributing to the development of MSc Biotechnology and MSc Microbiology as well as microbiological and biochemical aspects of the undergraduate curriculum in Biomedical Science.

0191 227 3975

Qualifications

PhD and BSc

Research Themes and Scholarly Interests

His current research interests revolve around the biosynthesis of the cell wall of pathogenic actinomycete bacteria exemplified by Mycobacterium tuberculosis, Rhodococcus equi and Corynebacterium diphtheriae.  The former is especially interesting as we face great challenges to find new treatments for multi-drug resistant strains causing human tuberculosis. Other major activities have been in investigating the modes of action/activation of anti-TB drugs and the inhibition of bacterial iron uptake as a means to prevent colonisation of cleaned environments, the latter as a collaboration with Dr David Tétard

Key Publications

Young M, Artsatbanov V, Beller HR, Chandra G, Chater KF, Dover LG,  Goh EB, Kahan T, Kaprelyants AS, Kyrpides N, Lapidus A, Lowry SR, Lykidis A, Mahillon J, Markowitz V, Mavromatis K, Mukamolova GV, Oren A, Rokem JS, Smith MC, Young DI, Greenblatt CL. Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium. J Bacteriol. 2010; 192(3):841-60.

Dover LG, What genomics has taught us about microbial cell wall biosynthesis (2007)
In Bacterial Pathogenomics (ed. Pallen, M.), ASM, Washington D.C.

Bacon J, Dover LG,  Hatch KA, Zhang Y Gomes, J.M, Kendall S, Wernisch L, Stoker NG, Butcher PD, Minnikin DE, Besra GS, Marsh PD. The lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. Microbiology 2007 153(5): 1435-1444

Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR Jr, Sacchettini JC. Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 204(1): 73-8.

Dover LG, Alahari A, Gratraud P, Gomes JM, Bhowruth V, Reynolds RC, Besra GS, Kremer L.  EthA, a Common Activator of Thiocarbamide-Containing Drugs Acting on Different Mycobacterial Targets. Antimicrob Agents Chemother. 2007 51(3): 1055-1063.

Dover LG,  Corsino PE, Daniels IR, Cocklin SL, Tatituri V, Besra GS, Futterer K. Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance. J Mol Biol. 2004 340(5):1095-105.

To view my Northumbria Research Link page click here


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