Professor Emile Rugamika Chimusa

My research has a focus on methodologies of improving the analysis of large-scale genomic studies such as genome-wide association, fine-mapping studies, admixture mapping, genomics of mixed ancestry populations and analysing genome wide patterns of variation within and between species to address fundamental questions in biology, anthropology, and medicine. My interest is to unlock genomics in healthcare through computational and statistical methods to understand the genomics and environment architecture of complex diseases, variation in drug/treatment response. This interest is extending in methodologies and developing tools for deconvoluting human genomics diversity to uncover the role of genetic and environmental factors in determining risk and susceptibility of communicable and non-communicable diseases. I develop Bioinformatics methods/tools pertinent to genetic and environmental determinants of susceptibility to complex diseases, drug responses, genome variation, microbial omics, and infectious diseases from both the host and pathogen perspectives to facilitate the transformation of genomics-driven clinical practice.

Our current range of developed Bioinformatics tools from functional genomics, post-Genome-wide Association Studies, disease risk prediction, Gene Ontology semantic similarity can be found at (https://github.com/echimusa).

I am actively involved in the development of bioinformatics and Omics Data Science educational courses to offer a unique opportunity in the use of bioinformatics and computational methods to access and harness large complicated high-throughput data and uncover meaningful information that could be used to understand molecular mechanisms and develop novel targeted therapeutics/diagnostic tools.

• Please visit the Pure Research Information Portal for further information
• Genetic Modifiers of Sickle Cell Anemia Phenotype in a Cohort of Angolan Children, Ginete, C., Delgadinho, M., Santos, B., Miranda, A., Silva, C., Guerreiro, P., Chimusa, E., Brito, M. 8 Apr 2024, In: Genes
• Network-based integrative multi-omics approach reveals biosignatures specific to COVID-19 disease phases, Agamah, F., Ederveen, T., Skelton, M., Martin, D., Chimusa, E., 't Hoen, P. 8 Jul 2024, In: Frontiers in Molecular Biosciences
• Network-based Multi-omics Disease–Drug Associations Reveal Drug Repurposing Candidates for Covid-19 Disease Phases, Agamah, F., Ederveen, T., Skelton, M., Martin, D., Chimusa, E., 't Hoen, P. 3 Jul 2024, In: Drug Repurposing
• Towards genomic medicine: a tailored next-generation sequencing panel for hydroxyurea pharmacogenomics in Tanzania, Nkya, S., Nzunda, C., Saukiwa, E., Kaywanga, F., Buberwa, E., Solomon, D., Christopher, H., Ngowi, D., Johansen, J., Urio, F., Mgaya, J., Karim, S., Alimohamed, M., Sangeda, R., Chamba, C., Chimusa, E., Novelli, E., Makani, J. 18 Jul 2024, In: BMC Medical Genomics
• Data standardization in the omics field, Rugamika, C., Kumuthini, J., Zass, L., Chaouch, M., Gill, Z., Ras, V., Mungloo-Dilmohamud, Z., Sathan, D., Ghoorah, A., Fadlelmola, F., Fields, C., Van Horn, J., Radouani, F., Konopko, M., Baichoo, S. Jan 2023, Genomic Data Sharing: Case Studies, Challenges, and Opportunities for Precision Medicine, Elsevier
• Genome-wide association study identifies novel candidate malaria resistance genes in Cameroon, Esoh, K., Apinjoh, T., Amambua-Ngwa, A., Nyanjom, S., Chimusa, E., Amenga-Etego, L., Wonkam, A., Achidi, E. 15 Jun 2023, In: Human Molecular Genetics
• Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans, Katsukunya, J., Soko, N., Naidoo, J., Rayner, B., Blom, D., Sinxadi, P., Chimusa, E., Dandara, M., Dzobo, K., Jones, E., Dandara, C. 30 May 2023, In: International Journal of Hypertension
• The African Society of Human Genetics successfully launches global data science workshops, Nembaware, V., Bennett, D., Chimusa, E., Chikowore, T., Daodu, R., Bitoungui, V., Williams, S., Fatumo, S., Healy, S., Seoighe, C., Wonkam, A., Landouré, G., Ndiaye, R., Dandara, C., Mutesa, L., Ramsay, M., El-Kamah, G., Sirugo, G., Makani, J., Sadki, K., Alimohamed, M., Nkya, S., Gaye, A., Ramesar, R., Choudhury, A., Happi, C., Munung, N., Kherji, N., Hotchkiss, J., Ras, V., Ghansay, A., Musanabaganwa, C., Esoh, K., Adadey, S., Coughlan, S. 1 Nov 2023, In: Trends in Genetics
• Whole genome sequencing reveals population diversity and variation in HIV-1 specific host genes, Thami, P., Choga, W., Dandara, C., O’Brien, S., Essex, M., Gaseitsiwe, S., Chimusa, E. 20 Dec 2023, In: Frontiers in Genetics
• A whole genome sequencing approach to anterior cruciate ligament rupture–a twin study in two unrelated families, Feldmann, D., Bope, C., Patricios, J., Chimusa, E., Collins, M., September, A. 6 Oct 2022, In: PLoS One

• Please visit the Pure Research Information Portal for further information
• Organising a conference, workshop, ...: AI and Data Science in Multi-Omics for Human Health 2023

Bioinformatics PhD July 01 2013

• Please visit the Pure Research Information Portal for further information
• Visit out Genomics Tools on Github