Professor Stephen Todryk

Professor

School: Geography and Natural Sciences

Stephen Todryk is Professor of Immunology within the Department of Applied Sciences.

Having received a BSc in Applied & Human Biology in Aston, Birmingham in 1989, Steve went on to work in an NHS Immunology lab in Oxford for two years. He then embarked on a PhD at Guys Hospital, London, studying immunity and vaccines against streptococci, which he completed in 1995. He carried out postdoctoral studies on cancer immunotherapy at the Cancer Research UK lab at the Hammersmith Hospital and at St George’s London, before setting up a group as a Principal Investigator at the University of Maynooth in Ireland in 2000. He relocated his lab to Trinity College Dublin where he was a Research Lecturer. He came back to the UK, to Oxford University, in 2004, to lead the study of human immunological aspects of malaria vaccine development with Adrian Hill.

Steve joined Northumbria University in 2007 as a Senior Lecturer, became Reader in 2010 and was awarded personal Chair of Immunology in 2012.

Steve has been a member of the British Society for Immunology (BSI) since 1990, and served on the BSI council and local committee. He is a committee member of the local branch of the Royal Society of Biology (RSB), where he is Fellow.

He is also on the Editorial Boards of the following international journals:

Immunology (Impact Factor 5.0)

PloS ONE (Impact Factor 2.7)

Scientific Reports (Impact Factor 4.0)

Frontiers in Immunology (impact factor 6.4)

Cells (impact factor 4.4)

Vaccines (impact factor 4.1)

Email Stephen

Research Themes and Scholarly Interests

immunology
Recent and current projects:

Anti-microbial immunity in the lung, in obstructive lung diseases

Allergic responses in the lung

Immune responses in Chronic Fatigue

Immune responses in Heart Disease and COVID-19

Key Publications

Please visit the Pure Research Information Portal for further information
A Comparison of Flow Cytometry-based versus ImmunoSpot- or Supernatant-based Detection of SARS-CoV-2 Spike-specific Memory B Cells in Peripheral Blood, Stylianou, G., Cookson, S., T. Nassif, J., Kirchenbaum, G., V. Lehmann, P., M. Todryk, S. 24 Dec 2025, In: Vaccines
Comparing the diagnostic specificity of flow cytometry-based probe staining and ELISPOT for detection of SARS-CoV-2 Spike-reactive memory B cells using defined cohorts of cryopreserved human PBMC 9313, Kirchenbaum, G., Stylianou, G., Cookson, S., Lehmann, P., Todryk, S. 20 Nov 2025, In: The Journal of Immunology
Editorial: Inflammaging and immunosenescence: role in aging-associated cardiovascular diseases, Barhoumi, T., Bouchareb, R., Alroqi, F., Nefzi, A., Todryk, S. 14 May 2025, In: Frontiers in Cardiovascular Medicine
Measuring Human Memory B Cells in Autoimmunity Using Enzyme-Linked ImmunoSpot, Stylianou, G., Kirchenbaum, G., Lehmann, P., Pearce, S., Todryk, S. 30 Apr 2025, In: Biomolecules
SARS-CoV-2 Infection or COVID-19 mRNA Vaccination Elicits Partially Different Spike-Reactive Memory B Cell Responses in Naïve Individuals, Yao, L., Becza, N., Stylianou, G., Tary-Lehmann, M., Todryk, S., Kirchenbaum, G., Lehmann, P. 3 Sep 2025, In: Vaccines
How Reliable Are Predictions of CD8+ T Cell Epitope Recognition? Lessons for Cancer, Lehmann, A., Lehmann, P., Todryk, S. 17 Apr 2024, In: Onco
Relationship between tcdA and tcdB genes of clostridium difficile with diarrhea duration in elderly patients: an immunosenescence effect, Wedari, N., Todryk, S. Dec 2024, In: Journal of Global Antimicrobial Resistance
The Bisdioxopiperazine ICRF-193 Attenuates LPS-induced IL-1β Secretion by Macrophages, Brindle, A., Bainbridge, C., Kumar, M., Todryk, S., Padget, K. 1 Feb 2024, In: Inflammation
Tracking Circulating HLA-Specific IgG-Producing Memory B Cells with the B-Cell ImmunoSpot Assay, Kervella, D., Heidt, S., Fairchild, R., Todryk, S., Bestard, O. 19 Mar 2024, Handbook of ELISPOT, New York, Springer
Engineering Approaches for Cellular Therapeutics and Diagnostics, Torun, H., Agrawal, P., Markwell, C., Fu, Y., Todryk, S., Moschos, S. 6 Apr 2023, Emerging Drug Delivery and Biomedical Engineering Technologies , Boca Raton, US, Taylor & Francis

Current and Recent Projects

Please visit the Pure Research Information Portal for further information
The role of maternal folate in childhood leukemia initiation; understanding the molecular mechanisms, McKay, J. (Principal Investigator), Todryk, S. (Co Investigator), World Cancer Research Fund International, 01/04/23 - 31/03/27, £346,625.00

PGR Supervision

Georgia Stylianou Development, optimisation and characterization of memory B cell ELISPOT in infectious diseases and autoimmunity Start Date: 01/10/2023
Georgia Stylianou Development, optimisation and characterization of memory B cell ELISPOT in infectious diseases and autoimmunity Start Date: 01/10/2023 End Date: 17/10/2025