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Dr Meera Soundararajan

Senior Lecturer

Department: Applied Sciences

Dr Meera Soundararajan is a Senior Lecturer in Biomedical Sciences who joined Northumbria University in 2011. 

Meera’s work during her PhD involved elucidating the mechanism of DNA interacting and modifying enzymes.  Her initial post-doctoral work was directed towards understanding the transcriptional regulation in Acute Myeloid Leukemia through characterising macromolecular assemblages on the promoter. She continued to work as a postdoctoral fellow at Oxford which involved structural and functional characterisation of signalling molecules belonging to receptor mediated and Phosphorylation dependent signalling pathways that directly involved pathogenesis of cancer and development of neurological disorders.

Meera Soundararajan

Qualifications

  • Biochemistry PhD June 30 2002
  • Fellow (FHEA) Higher Education Academy (HEA) 2014
  • Information not provided Biochemical Society 2011

Key Publications

  • Please visit the Pure Research Information Portal for further information
  • Epidermal growth factor receptor (EGFR) gene alteration and protein overexpression in Malaysian triple-negative breast cancer (TNBC) cohort, Zakaria, Z., Zulkifle, M., Wan Hasan, W., Azhari, A., Abdul Raub, S., Eswaran, J., Soundararajan, M., Syed Husain, S. 20 Sep 2019, In: OncoTargets and Therapy
  • Proteomics and bioinformatics analyses identify novel cellular roles outside mitochondrial function for human miro GTPases, Kay, L., Sangal, V., Black, G., Soundararajan, M. 1 Jan 2019, In: Molecular and Cellular Biochemistry
  • Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism, Peters, D., Kay, L., Eswaran, J., Lakey, J., Soundararajan, M. 2 Dec 2018, In: International Journal of Molecular Sciences
  • Understanding Miro GTPases, Kay, L., Pienaar, I., Cooray, R., Black, G., Soundararajan, M. 1 Sep 2018, In: Molecular Neurobiology
  • Impact of the apoptotic regulator DRAK2 in chronic lymphocytic leukemia, Ciardullo, C., Zhou, P., Willmore, E., Harrison, C., Hall, A., Eswaran, J., Soundararajan, M. 12 Apr 2016
  • Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A, Kay, L., Smulders-Srinivasan, T., Soundararajan, M. 9 Aug 2016, Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods, London, Elsevier
  • Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition, Soundararajan, M., Roos, A., Savitsky, P., Filippakopoulos, P., Kettenbach, A., Olsen, J., Gerber, S., Eswaran, J., Knapp, S., Elkins, J. 2013, In: Structure
  • Atypical GTPases as drug targets, Soundararajan, M., Eswaran, J. 2012, In: Anti-Cancer Agents in Medicinal Chemistry
  • Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing, Debdab, M., Carreaux, F., Renault, S., Soundararajan, M., Fedorov, O., Filippakopoulos, P., Lozach, O., Babault, L., Tahtouh, T., Baratte, B., Ogawa, Y., Hagiwara, M., Eisenreich, A., Rauch, U., Knapp, S., Meijer, L., Bazureau, J. 26 May 2011, In: Journal of Medicinal Chemistry
  • Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function, Kwiatkowski, N., Jelluma, N., Filippakopoulos, P., Soundararajan, M., Manak, M., Kwon, M., Choi, H., Sim, T., Deveraux, Q., Rottmann, S., Pellman, D., Shah, J., Kops, G., Knapp, S., Gray, N. 2010, In: Nature Chemical Biology

PGR Supervision

Laura Kay Characterisation of Atypical Human GTPases: Elucidation of Molecular Functions and Interactors Start: 01/10/2012


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