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Prof Iain Sutcliffe

Department: Applied Sciences

Iain studied for his first degree in Biochemistry at the University of Newcastle upon Tyne, where he stayed on to complete a PhD in microbial physiology, supervised by Dr Norman Shaw. Subsequent post-doctoral research notably included working with Professor Roy Russell and a Wellcome Trust Career Development Fellowship in Taxonomy (both in the Department of Oral Biology, University of Newcastle upon Tyne).

He was a Senior Lecturer at the University of Sunderland from 1996-2003 before moving to Northumbria, where he was promoted to Reader (2005), then Professor of Microbiology in 2007. From 2012 to 2019 he was the Research Lead for the Department of Applied Sciences and he is currently REF Lead for the Faculty of Health and Life Sciences.

Iain Sutcliffe

Key Publications

  • Please visit the Pure Research Information Portal for further information
  • Roadmap for naming uncultivated Archaea and Bacteria, Murray, A., Freudenstein, J., Gribaldo, S., Hatzenpichler, R., Hugenholtz, P., Kämpfer, P., Konstantinidis, K., Lane, C., Papke, R., Parks, D., Rossello-Mora, R., Stott, M., Sutcliffe, I., Thrash, J., Venter, S., Whitman, W., Acinas, S., Amann, R., Anantharaman, K., Armengaud, J., Baker, B., Barco, R., Bode, H., Boyd, E., Brady, C., Carini, P., Chain, P., Colman, D., DeAngelis, K., de los Rios, M., Estrada-de los Santos, P., Dunlap, C., Eisen, J., Emerson, D., Ettema, T., Eveillard, D., Girguis, P., Hentschel, U., Hollibaugh, J., Hug, L., Inskeep, W., Ivanova, E., Klenk, H., Li, W., Lloyd, K., Löffler, F., Makhalanyane, T., Moser, D., Nunoura, T., Palmer, M., Parro, V., Pedrós-Alió, C., Probst, A., Smits, T., Steen, A., Steenkamp, E., Spang, A., Stewart, F., Tiedje, J., Vandamme, P., Wagner, M., Wang, F., Hedlund, B., Reysenbach, A. 1 Aug 2020, In: Nature Microbiology
  • Mechanism of Phosphatidylglycerol Activation Catalyzed by Prolipoprotein Diacylglyceryl Transferase, Singh, W., Bilal, M., McClory, J., Dourado, D., Quinn, D., Moody, T., Sutcliffe, I., Huang, M. 22 Aug 2019, In: Journal of Physical Chemistry B
  • Refined Systematics of the Genus Rhodococcus Based on Whole Genome Analyses, Sangal, V., Goodfellow, M., Jones, A., Seviour, R., Sutcliffe, I. 2019, Biology of Rhodococcus
  • Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient, Ramdhan, N., Blom, J., Sutcliffe, I., Pereira-Ribeiro, P., Santos, C., Mattos-Guaraldi, A., Burkovski, A., Sangal, V. 1 Jul 2019, In: New Microbes and New Infections

Qualifications

Biochemistry PhD September 01 1985

PGR Supervision

  • Mian Munir Investigations of lipoprotein biosynthesis in bacteria Start: 09/01/2012
  • Craig Mantanona Cellular and behavioural interrogations of prominent neural output nuclei of the pedunculopontine nucleus for mechanistic understanding of their promise for therapeutic targeting in Parkinson’s disease Start: 18/09/2017

Professional Activity

  • Please visit the Pure Research Information Portal for further information
  • Editorial work: Antonie van Leeuwenhoek Journal of Microbiology (Journal) 2019
  • Editorial work: Frontiers in Microbiology (Journal) 2018
  • Membership of committee: Bergey's International Society for Microbial Systematics (External organisation) 2017
  • Membership of committee: International Committee for Systematics of Prokaryotes (External organisation) 2017
  • Oral presentation: Whole genome analyses support the taxonomic separation of “Rhodococcus equi” from other rhodococci 2014
  • Editorial work: Antonie van Leeuwenhoek Journal of Microbiology (Journal) 2009

Research Themes and Scholarly Interests

My research focuses on understanding the bacterial cell envelope as the interface between a bacterium and its environment, with a specific focus on the nature, biosynthesis and roles of membrane-anchored macromolecules, notably bacterial lipoproteins and lipoglycans. Several projects are focussed on understanding the role of the cell envelope in the biology of the important veterinary pathogen Rhodococcus (Prescottella) equi and related bacteria.

Understanding cell envelope diversity is also of importance for microbial taxonomy and studies of bacterial evolution, and I am particularly interested in the evolution of outer membranes. My work in taxonomy has progressed from an earlier chemotaxonomic approach to primarily using comparative genomics and in this regard I am active in developing the discipline of microbial systematics. I am currently in my second term (2020-2023) as Chair of the International Committee for Systematics of Prokaryotes (https://www.the-icsp.org/).


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