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Dr Luke Hughes

Assistant Professor

Department: Sport, Exercise and Rehabilitation

Dr Luke Hughes is an exercise physiologist specialising in clinical exercise and aerospace physiology. He obtained his PhD in clinical exercise physiology in 2019, which developing a novel exercise rehabilitation technique termed “blood flow restriction exercise”.

Research Themes and Scholarly Interests:

My research focusses on understanding the physiological mechanisms of health and deconditioning, and development of novel interventions to optimise human health, performance and rehabilitation in high-performance (e.g. professional/elite sport, human spaceflight) and clinical medicine populations. Within clinical medicine, my work focusses on the use of ‘blood flow restriction exercise’, a novel low-intensity exercise intervention, to improve health in deconditioned populations and improve post-surgical outcomes in several medical conditions and diseases. I have implemented this technique in the UK National Health Service, initially through clinical trials and now as part of standard rehabilitation. I am now working to develop blood flow restriction exercise as a countermeasure to improve astronaut health and mitigate deconditioning during spaceflight, and optimise post-flight rehabilitation outcomes.


Luke Hughes

  • Please visit the Pure Research Information Portal for further information
  • Acute hypoalgesic, neurophysiological and perceptual responses to low‐load blood flow restriction exercise and high‐load resistance exercise, Norbury, R., Grant, I., Woodhead, A., Hughes, L., Tallent, J., Patterson, S. 1 May 2024, In: Experimental Physiology
  • Idiosyncratic bone responses to blood flow restriction exercise: new insights and future directions, Hughes, L., Centner, C. 1 Feb 2024, In: Journal of Applied Physiology
  • It's time to regulate - The importance of accurate surgical-grade tourniquet autoregulation in blood flow restriction exercise applications, Hughes, L., Swain, P., Lai, T., McEwen, J. 1 May 2024, In: Physical Therapy in Sport
  • No sex differences in oxygen uptake or extraction kinetics in the moderate or heavy exercise intensity domains, Solleiro Pons, M., Bernert, L., Hume, E., Hughes, L., Williams, Z., Burnley, M., Ansdell, P. 1 Mar 2024, In: Journal of Applied Physiology
  • Blood Flow Restriction Training and Return to Play Following Knee Surgery, Hughes, L., Patterson, S. 9 Oct 2023, Knee Arthroscopy and Knee Preservation Surgery, Cham, Switzerland, Springer
  • Editorial: Clinical application and impact of blood-flow-restriction training, Behringer, M., Franz, A., Hughes, L. 20 Feb 2023, In: Frontiers in Physiology
  • A call to action for blood flow restriction training in older adults with or susceptible to sarcopenia: A systematic review and meta-analysis, Cahalin, L., Formiga, M., Anderson, B., Cipriano Jr., G., Hernandez, E., Owens, J., Hughes, L. 15 Aug 2022, In: Frontiers in Physiology
  • Beneficial Role of Blood Flow Restriction Exercise in Heart Disease and Heart Failure Using the Muscle Hypothesis of Chronic Heart Failure and a Growing Literature, Cahalin, L., Formiga, M., Owens, J., Anderson, B., Hughes, L. 6 Jul 2022, In: Frontiers in Physiology
  • Optimization of Exercise Countermeasures to Spaceflight Using Blood Flow Restriction, Hughes, L., Hackney, K., Patterson, S. 1 Jan 2022, In: Aerospace medicine and human performance
  • Aerobic exercise with blood flow restriction causes local and systemic hypoalgesia and increases circulating opioid and endocannabinoid levels, Hughes, L., Grant, I., Patterson, S. 1 Nov 2021, In: Journal of Applied Physiology

Luke Gray Optimising the Therapeutic Effects of Blood Flow Restriction Exercise within UK Defence Rehabilitation Start Date: 01/10/2023

Philosophy PhD July 30 2019

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