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Dr Luke Hughes

Associate Professor

School: Sport Exercise and Rehabilitation

Dr Luke Hughes is an exercise physiologist specialising in clinical exercise and aerospace physiology. He obtained his PhD in clinical exercise physiology in 2019, which developing a novel exercise rehabilitation technique termed “blood flow restriction exercise”.

Research Themes and Scholarly Interests:

My research focusses on understanding the physiological mechanisms of health and deconditioning, and development of novel interventions to optimise human health, performance and rehabilitation in high-performance (e.g. professional/elite sport, human spaceflight) and clinical medicine populations. Within clinical medicine, my work focusses on the use of ‘blood flow restriction exercise’, a novel low-intensity exercise intervention, to improve health in deconditioned populations and improve post-surgical outcomes in several medical conditions and diseases. I have implemented this technique in the UK National Health Service, initially through clinical trials and now as part of standard rehabilitation. I am now working to develop blood flow restriction exercise as a countermeasure to improve astronaut health and mitigate deconditioning during spaceflight, and optimise post-flight rehabilitation outcomes.

 

  • Please visit the Pure Research Information Portal for further information
  • Autoregulation during blood flow restricted exercise offers no additional benefit on thigh muscle hypertrophy and strength adaptations in trained participants: a randomized within-subject 8-week trial, Akçay, N., Rolnick, N., Keskin, K., Kamiş, O., Köremezli Keskin, N., Başdemirci, O., Sofuoğlu, C., Hughes, L. 23 Feb 2026, In: Frontiers in Physiology
  • Editorial: Impact of blood flow restriction device features and methodological considerations on acute- and longitudinal responses to blood flow restricted exercise, Rolnick, N., Werner, T., Clarkson, M., Hughes, L. 6 Mar 2026, In: Frontiers in Sports and Active Living
  • Evaluating the effectiveness of blood flow restriction training in older adults: An overview of systematic reviews, de Queiros, V., Rolnick, N., Jaggers, J., Fortunato, I., Albuquerque Filho, N., Gonzaga, J., da Cunha Lisboa, M., Hughes, L. 1 May 2026, In: Sports Medicine and Health Science
  • Hypogravity Simulation using the Variable Gravity Suspension System: A Technical Report, Swain, P., Swain, A., Santos, F., Hughes, L., Lindsay, K., Lomax, I., Bruce-Martin, C., Caplan, N. 1 Apr 2026, In: Experimental Physiology
  • Jumping in simulated lunar gravity with blood flow restriction as a potential exercise countermeasure: The acute physiological effects, Illingworth, B., Hughes, L., Sheard, N., Latue, C., Swain, P., Caplan, N., Santos, F. 18 May 2026, In: Experimental Physiology
  • Neuromotor changes in postural control following bed rest, Ritzmann, R., Centner, C., Hughes, L., Waldvogel, J., Marusic, U. 15 Jan 2026, In: The Journal of Physiology
  • The dynamics of neuromuscular resilience across the lifespan: Ageing, disuse and intervention, Centner, C., Ritzmann, R., Marusic, U., Hughes, L. 15 Jan 2026, In: The Journal of Physiology
  • The effects of high-pressure versus low-pressure blood flow restriction resistance exercise in individuals with lower limb musculoskeletal injuries and persistent pain: a randomised controlled trial, Gray, L., Coppack, R., Barker-Davies, R., Cassidy, R., Bennett, A., Caplan, N., Atkinson, G., Bradshaw, L., Hughes, L., Ladlow, P. 1 May 2026, In: Physical Therapy in Sport
  • Variability in spatial and temporal gait dynamics during aging: a narrative review on the role of the neural system, Centner, C., Ritzmann, R., Marusic, U., Hughes, L. 1 May 2026, In: Archives of Gerontology and Geriatrics
  • Blood flow restriction exercise during microgravity exposure in parabolic flight, Laflamme, Y., Chassé, E., Hughes, L. 6 Aug 2025, In: Experimental Physiology
  • Luke Gray Optimising the Therapeutic Effects of Blood Flow Restriction Exercise within UK Defence Rehabilitation Start Date: 01/10/2023
  • Bradley Barbour Walking and Jumping on the Moon with Blood Flow Restriction: A Spaceflight Countermeasure for Exploration Class Missions Start Date: 01/10/2024
  • Michael Dawes TBC Start Date: 01/03/2026
Philosophy PhD July 30 2019

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